在南非陆生小型哺乳动物中尝试对热双态性人类真菌病原体非洲埃默菌进行分子检测。
Attempted molecular detection of the thermally dimorphic human fungal pathogen Emergomyces africanus in terrestrial small mammals in South Africa.
作者信息
Cronjé Nadine, Schwartz Ilan S, Retief Liezl, Bastos Armanda D S, Matthee Sonja, Preiser Wolfgang, Bennett Nigel C, Maphanga Tsidiso, Govender Nelesh P, Colebunders Robert, Kenyon Chris
机构信息
Division of Medical Virology, Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Global Health Institute, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
出版信息
Med Mycol. 2018 Jun 1;56(4):510-513. doi: 10.1093/mmy/myx065.
The ecological niche of Emergomyces africanus (formerly Emmonsia species), a dimorphic fungus that causes an AIDS-related mycosis in South Africa, is unknown. We hypothesized that natural infection with E. africanus occurs in wild small mammals. Using molecular detection with primers specific for E. africanus, we examined 1402 DNA samples from 26 species of mole-rats, rodents, and insectivores trapped in South Africa that included 1324 lung, 37 kidney, and 41 liver specimens. DNA of E. africanus was not detected in any animals. We conclude that natural infection of wild small mammals in South Africa with E. africanus has not been proven.
非洲埃默菌（以前的艾蒙斯菌属物种）是一种双态真菌，在南非可引起与艾滋病相关的真菌病，其生态位尚不清楚。我们推测非洲埃默菌的自然感染发生在野生小型哺乳动物中。我们使用针对非洲埃默菌的特异性引物进行分子检测，检测了从南非捕获的26种鼹形鼠、啮齿动物和食虫动物的1402份DNA样本，其中包括1324份肺标本、37份肾标本和41份肝标本。在任何动物中均未检测到非洲埃默菌的DNA。我们得出结论，南非野生小型哺乳动物被非洲埃默菌自然感染尚未得到证实。
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