无电化学氧化剂促进的脱氢 C-H/S-H 交叉偶联反应。
Electrocatalytic Oxidant-Free Dehydrogenative C-H/S-H Cross-Coupling.
机构信息
College of Chemistry and Molecular Sciences, Institute for Advanced Studies (IAS), Wuhan University, Wuhan, 430072, Hubei, P.R. China.
State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, P.R. China.
出版信息
Angew Chem Int Ed Engl. 2017 Mar 6;56(11):3009-3013. doi: 10.1002/anie.201700012. Epub 2017 Feb 8.
An environmentally friendly electrocatalytic protocol has been developed for dehydrogenative C-H/S-H cross-coupling. This method enabled C-S bond formation under catalyst- and oxidant-free conditions. Under undivided electrolysis conditions, various aryl/heteroaryl thiols and electron-rich arenes afforded the C-S bond-formation products in 24-99 % yield. A preliminary mechanistic study indicated that the generation of aryl radical cation intermediates is key to the success of this transformation.
已开发出一种用于脱氢 C-H/S-H 交叉偶联的环保电催化协议。该方法在无催化剂和氧化剂的条件下实现了 C-S 键的形成。在无分隔电解条件下，各种芳基/杂芳基硫醇和富电子芳基化合物以 24-99%的产率得到 C-S 键形成产物。初步的机理研究表明，芳基自由基阳离子中间体的生成是该转化成功的关键。
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