Huang Xin, Chen Yongqi, Zhen Shan, Song Lijuan, Gao Mingqi, Zhang Panke, Li Heng, Yuan Bingxin, Yang Guanyu
College of Chemistry and Molecular Engineering , Zhengzhou University , Zhengzhou , Henan 450001 , China.
China Tobacco Henan Industry Co., Ltd. , Zhengzhou , Henan 450001 , China.
J Org Chem. 2018 Jul 20;83(14):7331-7340. doi: 10.1021/acs.joc.7b02718. Epub 2018 Jan 24.
Organosulfides have great significance and value in synthetic and biological chemistry. To establish a versatile and green methodology for C-S bond generation, we successfully developed a new aerobic cross-dehydrogenative coupling of C-H and S-H to synthesize aryl sulfides in water, utilizing CoPcS as the catalyst and O as the oxidant. This protocol shows great tolerance of a wide range of substrates. A large variety of organosulfur compounds were produced in modest to excellent yields.
有机硫化物在合成化学和生物化学中具有重要意义和价值。为了建立一种通用且绿色的C-S键生成方法，我们成功开发了一种新的有氧C-H和S-H交叉脱氢偶联反应，以CoPcS为催化剂、O为氧化剂，在水中合成芳基硫化物。该方法对多种底物具有良好的耐受性，能以中等至优异的产率制备多种有机硫化合物。
