系统性红斑狼疮患者培养淋巴细胞白细胞介素 -2 的产生及反应降低。
Decreased production of and response to interleukin-2 by cultured lymphocytes from patients with systemic lupus erythematosus.
作者信息
Alcocer-Varela J, Alarcón-Segovia D
出版信息
J Clin Invest. 1982 Jun;69(6):1388-92. doi: 10.1172/jci110579.
Abstract
We studied the production of and response to interleukin-2 (IL-2) by peripheral blood T lymphocytes from 19 systemic lupus erythematosus (SLE) patients who received no treatment at the time they were studied. Eight had active disease and the rest were in remission. Results were compared with those obtained in 12 healthy subjects of similar age. T cells from SLE patients, whether activated with phytohemagglutinin or in autologous mixed lymphocyte reactions, were found to yield little IL-2, to have a low response to IL-2 from its own, or other sources, and to absorb IL-2 poorly, IL-2 produced by SLE cells, albeit scant, was absorbed normally by activated T cells from normal subjects. Our findings may contribute to the understanding of the immunoregulatory defect in SLE.
摘要
我们研究了19例系统性红斑狼疮（SLE）患者外周血T淋巴细胞白细胞介素-2（IL-2）的产生及反应情况，这些患者在研究时未接受治疗。其中8例患有活动性疾病，其余处于缓解期。将结果与12名年龄相仿的健康受试者的结果进行了比较。发现SLE患者的T细胞，无论是用植物血凝素激活还是在自体混合淋巴细胞反应中，产生的IL-2很少，对自身或其他来源的IL-2反应较低，且对IL-2的吸收较差。SLE细胞产生的IL-2虽然很少，但能被正常受试者的活化T细胞正常吸收。我们的研究结果可能有助于理解SLE中的免疫调节缺陷。
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