Karakousis C P, Emrich L J, Vesper D S
Department of Surgical Oncology, Roswell Park Memorial Institute, Buffalo, NY 14263.
Arch Surg. 1989 Nov;124(11):1297-300. doi: 10.1001/archsurg.1989.01410110055011.
Of 54 patients with soft-tissue sarcomas of the proximal part of the lower extremity, 2 patients (4%) were treated with amputation, while 52 patients (96%) were treated with limb-preserving resection. Adjuvant postoperative irradiation was applied selectively when the minimum margin was less than 2 cm (22 patients). Technical improvements in exposure, resection of involved vessels or nerve, and preservation of function permitted a high rate of limb salvage with satisfactory function. At a median follow-up of 30 months for those subjects still alive, the 5-year disease-free survival rate was 65%, and only 3 patients (6%) had had a local recurrence.
在54例下肢近端软组织肉瘤患者中，2例（4%）接受了截肢治疗，而52例（96%）接受了保肢切除。当最小切缘小于2 cm时，有22例患者选择性地接受了术后辅助放疗。暴露、受累血管或神经切除以及功能保留方面的技术改进使得保肢率较高且功能满意。对于仍存活的患者，中位随访30个月时，5年无病生存率为65%，仅有3例（6%）出现局部复发。
