Gore Charusheela R, Panicker N K, Kumar Harsh, Buch Archana, Chandanwale S S
Department of Pathology, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pimpri, Pune, Maharashtra, India.
J Cytol. 2017 Jan-Mar;34(1):56-58. doi: 10.4103/0970-9371.197622.
Signet ring cell lymphomas are the proliferations of malignant lymphoid cells containing cytoplasmic vacuoles or globules which displace the nuclei, imparting it a signet ring appearance. This rare tumor is a variant of non-Hodgkin lymphoma. Signet ring appearance is due to cytoplasmic accumulation of immunoglobulin or vacuoles derived from multivesicular bodies. These cells, particularly with cytoplasmic vacuoles, may be mistaken for adenocarcinoma cells. We are presenting one such case where immunofluorescence helped us to demonstrate the immunoglobulins on fine needle aspiration smears. This is an innovative technique and has not been reported earlier. Our aim of presenting this case is to review the awareness of this rare lymphoma among pathologists to give due consideration for avoiding inappropriate investigations and treatment.
印戒细胞淋巴瘤是一种恶性淋巴样细胞的增殖性疾病，这些细胞含有可使细胞核移位的细胞质空泡或小球，使其呈现印戒样外观。这种罕见的肿瘤是非霍奇金淋巴瘤的一种变体。印戒样外观是由于免疫球蛋白在细胞质中积聚或来源于多囊泡体的空泡所致。这些细胞，尤其是带有细胞质空泡的细胞，可能会被误认为腺癌细胞。我们在此呈现这样一例病例，其中免疫荧光技术帮助我们在细针穿刺涂片上证实了免疫球蛋白的存在。这是一项创新技术，此前尚未见报道。我们呈现此病例的目的是提高病理学家对这种罕见淋巴瘤的认识，以便在诊断时给予充分考虑，避免不恰当的检查和治疗。
