McCluggage W G, Bharucha H, el-Agnaf M, Toner P G
Department of Pathology, Royal Hospitals Trust, Belfast.
J Clin Pathol. 1995 Mar;48(3):275-8. doi: 10.1136/jcp.48.3.275.
A case of signet-ring cell lymphoma affecting the bone marrow and diagnosed by bone marrow trephine biopsy is reported. Normal marrow was replaced totally by cells with large central vacuoles, many of which displaced the nucleus to the periphery of the cell, imparting a signet-ring appearance. Initially, the favoured morphological diagnosis was metastatic signet-ring adenocarcinoma, but on immunocytochemistry the tumour cells were strongly positive for CD45 (leucocyte common antigen) and the B cell marker CD20 (L26). Electron microscopy revealed electron-lucent vacuoles with no discernable internal structure. The tumour was classified as a high grade centroblastic lymphoma using the upgraded Kiel classification. Despite chemotherapeutic treatment, the patient died during an episode of septicaemic shock within two months of presentation.
报告了一例通过骨髓环钻活检诊断为累及骨髓的印戒细胞淋巴瘤病例。正常骨髓完全被具有大的中央空泡的细胞取代，其中许多空泡将细胞核挤向细胞周边，呈现印戒样外观。最初，形态学上最支持的诊断是转移性印戒腺癌，但免疫细胞化学显示肿瘤细胞对CD45（白细胞共同抗原）和B细胞标志物CD20（L26）呈强阳性。电子显微镜检查发现电子透亮的空泡，无明显内部结构。根据改良的基尔分类，该肿瘤被归类为高级别中心母细胞淋巴瘤。尽管进行了化疗，但患者在就诊后两个月内死于败血症性休克发作。
