Burkard Markus, Leischner Christian, Lauer Ulrich M, Busch Christian, Venturelli Sascha, Frank Jan
Institute of Physiology, Department of Physiology I, Medical University Hospital, Tuebingen, Germany.
Department of Internal Medicine VIII, Medical University Hospital, Tuebingen, Germany.
J Nutr Biochem. 2017 Aug;46:1-12. doi: 10.1016/j.jnutbio.2017.01.006. Epub 2017 Jan 24.
Flavonoids are a large group of secondary plant metabolites present in the diet with numerous potentially health-beneficial biological activities. In addition to antioxidant, anti-inflammatory, cholesterol-lowering, and many other biological functions reported in the literature, flavonoids appear to inhibit cancer cell proliferation and stimulate immune function. Although the immunomodulatory potential of flavonoids has been intensively investigated, only little is known about their impact on natural killer (NK) cells. Enhancing NK cell activity, however, would have strong implications for a possible clinical use of flavonoids, especially in the treatment and prevention of diseases like cancer and viral infections. Therefore, the purpose of this review is to summarize the currently available information on NK cell modulation by flavonoids. Many of the structurally diverse flavonoids stimulate NK cell activity and have thus great potential as diet-derived immune-modulatory chemopreventive agents and may even serve as therapeutic compounds or lead structures for the development of novel drugs for the treatment of both malignant and viral diseases.
黄酮类化合物是饮食中存在的一大类植物次生代谢产物，具有许多潜在的有益健康的生物活性。除了文献中报道的抗氧化、抗炎、降胆固醇和许多其他生物学功能外，黄酮类化合物似乎还能抑制癌细胞增殖并刺激免疫功能。尽管黄酮类化合物的免疫调节潜力已得到深入研究，但关于它们对自然杀伤（NK）细胞的影响却知之甚少。然而，增强NK细胞活性对于黄酮类化合物的临床应用可能具有重要意义，尤其是在癌症和病毒感染等疾病的治疗和预防方面。因此，本综述的目的是总结目前关于黄酮类化合物对NK细胞调节作用的现有信息。许多结构多样的黄酮类化合物可刺激NK细胞活性，因此作为饮食来源的免疫调节化学预防剂具有巨大潜力，甚至可作为治疗化合物或新型药物开发的先导结构，用于治疗恶性疾病和病毒性疾病。
