钒诱导的血红素合成损伤。
Vanadium induced impairment of haem synthesis.
作者信息
Missenard C, Hansen G, Kutter D, Kremer A
机构信息
Laboratoire Clinique Eich, Centre Universitaire de Luxembourg.
出版信息
Br J Ind Med. 1989 Oct;46(10):744-7. doi: 10.1136/oem.46.10.744.
Biochemical and haematological profiles of workers exposed to vanadium were compared with those of non-exposed age matched subjects. A significantly positive and dose related correlation between serum vanadium and zinc protoporphyrin (ZPP) was observed. Normal lead concentrations excluded this heavy metal as a possible cause. Inhibition of the reduction of Fe to Fe++ by vanadium is discussed as the possible cause of interference of vanadium with haem synthesis. Iron and iron binding capacity were found to be significantly lower and ferritin significantly higher in the population exposed to vanadium. Strong inter-individual variations do not allow an explanation of this interference with iron metabolism.
将接触钒的工人的生化和血液学指标与未接触钒的年龄匹配的受试者的指标进行了比较。观察到血清钒与锌原卟啉（ZPP）之间存在显著的正相关且与剂量相关。正常的铅浓度排除了这种重金属作为可能原因。讨论了钒抑制Fe还原为Fe++可能是钒干扰血红素合成的原因。发现接触钒的人群中铁和铁结合能力显著降低，而铁蛋白显著升高。个体间的强烈差异无法解释这种对铁代谢的干扰。
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