Department of Psychiatry, Centre of Excellence in Mental Health, PGIMER Dr RML Hospital, New Delhi, India.
Indo-US Projects, Department of Psychiatry, Centre of Excellence in Mental Health, PGIMER Dr RML Hospital, New Delhi, India.
Asian J Psychiatr. 2019 Jan;39:48-52. doi: 10.1016/j.ajp.2018.11.016. Epub 2018 Nov 27.
Obsessive compulsive symptoms are often present in persons with schizophrenia. Adequately powered studies to evaluate the effect of such symptoms in the course of the disorder, are few.
We aimed to estimate the prevalence and type of obsessive-compulsive symptoms in persons with schizophrenia.
We evaluated 200 outpatients with schizophrenia (DSM-V) on the Positive and Negative Symptom Scale (PANSS) and the Yale Brown Obsessive Compulsive Scale (YBOCS). Participants with or without obsessive compulsive symptoms were matched on age, gender and age of onset of schizophrenia. Appropriate analysis by comparisons and correlations were performed.
Prevalence of obsessive-compulsive symptoms was 18.5% (n = 37/200). Most common obsession was contamination and compulsion was cleaning/washing with a prevalence of 51.35% and 63.33% respectively. There were no significant differences between the two groups on age, gender, marital status, residence, age of onset or total duration of illness of schizophrenia. The OC symptoms group had significantly higher general psychopathology and PANSS total scores. There was significant positive correlation between YBOCS total obsession scores (To) and total PANSS scores (r = 0.358) (p = 0.030), as well as PANSS general psychopathology subscale scores (Gt) (r = 0.395) (p = 0.016) and finally between total YBOCS scores (To + Tc) and PANSS positive subscale scores (Pt)(r = 0.344) (p = 0.037).
There was a significant subgroup of schizophrenia patients (almost one fifth) who complained of obsessive-compulsive symptoms. This group reported significantly higher general psychopathology and could thus be said to be more seriously ill, in an adequately powered cross sectional study.
强迫症症状在精神分裂症患者中经常出现。评估此类症状在疾病过程中的影响的充分有力的研究很少。
我们旨在评估精神分裂症患者中强迫症症状的患病率和类型。
我们用阳性和阴性症状量表（PANSS）和耶鲁-布朗强迫量表（YBOCS）评估了 200 名精神分裂症门诊患者（DSM-V）。将伴有或不伴有强迫症状的患者按年龄、性别和精神分裂症发病年龄进行匹配。进行了适当的比较和相关性分析。
强迫症症状的患病率为 18.5%（n=37/200）。最常见的强迫观念是污染，强迫行为是清洁/洗涤，患病率分别为 51.35%和 63.33%。两组在年龄、性别、婚姻状况、居住地、发病年龄或精神分裂症总病程方面无显著差异。OC 症状组的一般精神病学和 PANSS 总分明显较高。YBOCS 总分（To）与 PANSS 总分（r=0.358）（p=0.030）以及 PANSS 一般精神病学分量表得分（Gt）（r=0.395）（p=0.016）呈显著正相关，最后总 YBOCS 得分（To+Tc）与 PANSS 阳性分量表得分（Pt）（r=0.344）（p=0.037）呈显著正相关。
在精神分裂症患者中有一个显著的亚组（几乎五分之一）抱怨有强迫症症状。在一项充分有力的横断面研究中，这一组报告的一般精神病学症状明显更高，因此可以说病情更严重。
