Ly Verena, Bottelier Marco, Hoekstra Pieter J, Arias Vasquez Alejandro, Buitelaar Jan K, Rommelse Nanda N
Karakter, Child and Adolescents Psychiatry, Reinier Postlaan 12, 6525 GC, Nijmegen, The Netherlands.
Department of Cognitive Neuroscience and Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands.
Eur Child Adolesc Psychiatry. 2017 Sep;26(9):1067-1079. doi: 10.1007/s00787-017-0959-1. Epub 2017 Feb 11.
Nutrition plays an important role in neurodevelopment. This insight has led to increasing research into the efficacy of nutrition-related interventions for treating neurodevelopmental disorders. This review discusses an elimination diet as a treatment for attention deficit hyperactivity disorder and autism spectrum disorder, with a focus on the efficacy of the food additives exclusion diet, gluten-free/casein-free diet and oligoantigenic diet. Furthermore, we discuss the potential mechanisms of elimination diets' effects in these neurodevelopmental disorders. The main candidate mechanism is the microbiome-gut-brain axis possibly involving complex interactions between multiple systems, including the metabolic, immune, endocrine, and neural system. We conclude with practical implications and future directions into the investigation of an elimination diet's efficacy in the treatment of attention deficit hyperactivity disorder and autism spectrum disorder.
营养在神经发育中起着重要作用。这一认识促使人们对营养相关干预措施治疗神经发育障碍的疗效进行越来越多的研究。本综述讨论了排除饮食作为治疗注意力缺陷多动障碍和自闭症谱系障碍的一种方法，重点关注食品添加剂排除饮食、无麸质/无酪蛋白饮食和低抗原饮食的疗效。此外，我们还讨论了排除饮食在这些神经发育障碍中发挥作用的潜在机制。主要的候选机制是微生物群-肠道-脑轴，可能涉及多个系统之间的复杂相互作用，包括代谢、免疫、内分泌和神经系统。我们最后阐述了排除饮食在治疗注意力缺陷多动障碍和自闭症谱系障碍疗效研究方面的实际意义和未来方向。
