Wang Wen-Chen, Xia Yan-Min, Yang Bo, Su Xiang-Ni, Chen Jia-Kuan, Li Wei, Jiang Tao
Department of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University.
Department of Thoracic Surgery, Tianjin First Center Hospital.
Biol Pharm Bull. 2017 May 1;40(5):583-593. doi: 10.1248/bpb.b16-00756. Epub 2017 Feb 10.
Tyrosol (Tyr) is a natural antioxidant that displays anti-oxidant and anti-inflammatory properties. The present study aimed to investigate the effect and mechanism of Tyr on lipopolysaccharide (LPS)-induced acute lung injury (ALI). In a mouse model, we found that pretreatment with Tyr significantly improved survival rate, attenuated lung permeability, ameliorated histopathological alterations, reduced expression of the inflammatory mediators and improved expression of the antioxidant enzyme. Further study revealed that Tyr markedly inhibited nuclear factor-κB (NF-κB) and activator protein-1 (AP-1) activation at both in vivo and in vitro levels. To investigate the underlying mechanism, we examined the impact of Tyr on the heme oxygenase (HO)-1/nuclear factor erythroid-2 related factor 2 (Nrf2) pathway in vivo and in vitro. The results showed that Tyr significantly improved the expression of HO-1 and the activation of Nrf2. This study offers novel evidence to support the efficacy of Tyr against ALI, which helps to clarify the underlying causes of the therapeutic effects behind Tyr.
酪醇（Tyr）是一种具有抗氧化和抗炎特性的天然抗氧化剂。本研究旨在探讨酪醇对脂多糖（LPS）诱导的急性肺损伤（ALI）的影响及其机制。在小鼠模型中，我们发现酪醇预处理可显著提高存活率、降低肺通透性、改善组织病理学改变、减少炎症介质表达并提高抗氧化酶表达。进一步研究表明，酪醇在体内和体外水平均显著抑制核因子κB（NF-κB）和活化蛋白1（AP-1）的激活。为探究潜在机制，我们在体内和体外研究了酪醇对血红素加氧酶（HO）-1/核因子红细胞2相关因子2（Nrf2）通路的影响。结果显示，酪醇显著提高了HO-1的表达和Nrf2的激活。本研究提供了新的证据支持酪醇对ALI的疗效，有助于阐明酪醇治疗作用的潜在原因。
