Hashem-Dabaghian Fataneh, Agah Shahram, Taghavi-Shirazi Maryam, Ghobadi Ali
Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences, Tehran, IR Iran.
Department of Gastroenterology, Iran University of Medical Sciences, Tehran, IR Iran.
Iran Red Crescent Med J. 2016 Jun 21;18(11):e23771. doi: 10.5812/ircmj.23771. eCollection 2016 Nov.
Gastric is extremely common worldwide.
The aim of this study was to assess the effectiveness of combination of and honey (Dosin) in eradication of gastric infection.
Nineteen patients who had positive result for infection by urea breath test (UBT) without a past history of peptic ulcer, gastric cancer or gastrointestinal bleeding, were suggested to receive one teaspoon of the mixture of Dosin (6 g/day of as ground seeds and 12 g/day of honey) three times a day after meals for two weeks. The second UBT was used to detect the presence of four weeks after completion of the test. In addition, symptoms of dyspepsia were scored before and after the study and analyzed with Wilcoxon signed-rank test.
Fourteen patients completed the study. Negative UBT was observed in 57.1% (8/14) of participants after intervention. The median and interquartile range (IQR) of total dyspepsia symptoms was significantly reduced from 5.5 (5 - 12) to 1 (0 - 4) (P = 0.005). All the patients tolerated Dosin except for one who was excluded due to mild diarrhea. No serious adverse events were reported.
Dosin was concluded to be an anti and an anti-dyspeptic agent. Further studies are recommended to investigate the effect of Dosin plus antibiotics (concurrently or following another) on gastric infection.
胃炎在全球极为常见。
本研究旨在评估[某种物质]与蜂蜜（多辛）联合使用在根除胃部感染方面的有效性。
19例尿素呼气试验（UBT）检测幽门螺杆菌感染呈阳性且无消化性溃疡、胃癌或胃肠道出血病史的患者，被建议每日三次，每次服用一茶匙多辛混合物（磨碎的种子形式的[某种物质]6克/天和蜂蜜12克/天），餐后服用，持续两周。在试验完成四周后，使用第二次UBT检测幽门螺杆菌的存在情况。此外，在研究前后对消化不良症状进行评分，并采用Wilcoxon符号秩检验进行分析。
14例患者完成了研究。干预后，57.1%（8/14）的参与者UBT检测呈阴性。消化不良症状总分的中位数和四分位间距（IQR）从5.5（5 - 12）显著降至1（0 - 4）（P = 0.005）。除1例因轻度腹泻被排除外，所有患者对多辛耐受性良好。未报告严重不良事件。
得出多辛是一种抗幽门螺杆菌和抗消化不良药物的结论。建议进一步研究调查多辛加抗生素（同时或先后使用）对胃部幽门螺杆菌感染的影响。
