Herrou Julien, Crosson Sean, Fiebig Aretha
Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.
Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA; Department of Microbiology, University of Chicago, Chicago, IL, USA.
Curr Opin Microbiol. 2017 Apr;36:47-54. doi: 10.1016/j.mib.2017.01.008. Epub 2017 Feb 11.
Sensor histidine kinases regulate adaptive cellular responses to changes in the chemical or physical state of the environment. HWE/HisKA2-family kinases comprise a subset of histidine kinases that is defined by unique sequence motifs in both the catalytic and non-catalytic regions. Recent crystal structures have defined conserved intramolecular interactions that inform models of kinase regulation that are unique to the HWE/HisKA2 superfamily. Emerging genetic, biochemical and genomic data indicate that, unlike typical histidine kinases, HWE/HisKA2 kinases do not generally signal via classical DNA-binding response regulators. Rather, these unusual kinases are often part of atypical regulatory pathways that control changes in gene expression via modulation of protein-protein interactions or transcription anti-termination.
传感组氨酸激酶调节细胞对环境化学或物理状态变化的适应性反应。HWE/HisKA2家族激酶是组氨酸激酶的一个子集，由催化区域和非催化区域中的独特序列基序定义。最近的晶体结构确定了保守的分子内相互作用，这些相互作用为HWE/HisKA2超家族特有的激酶调节模型提供了信息。新出现的遗传、生化和基因组数据表明，与典型的组氨酸激酶不同，HWE/HisKA2激酶通常不通过经典的DNA结合反应调节因子进行信号传导。相反，这些不同寻常的激酶通常是不典型调节途径的一部分，通过调节蛋白质-蛋白质相互作用或转录抗终止来控制基因表达的变化。
