HWE/HisKA2家族传感组氨酸激酶的结构与功能
Structure and function of HWE/HisKA2-family sensor histidine kinases.
作者信息
Herrou Julien, Crosson Sean, Fiebig Aretha
机构信息
Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.
Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA; Department of Microbiology, University of Chicago, Chicago, IL, USA.
出版信息
Curr Opin Microbiol. 2017 Apr;36:47-54. doi: 10.1016/j.mib.2017.01.008. Epub 2017 Feb 11.
Abstract
Sensor histidine kinases regulate adaptive cellular responses to changes in the chemical or physical state of the environment. HWE/HisKA2-family kinases comprise a subset of histidine kinases that is defined by unique sequence motifs in both the catalytic and non-catalytic regions. Recent crystal structures have defined conserved intramolecular interactions that inform models of kinase regulation that are unique to the HWE/HisKA2 superfamily. Emerging genetic, biochemical and genomic data indicate that, unlike typical histidine kinases, HWE/HisKA2 kinases do not generally signal via classical DNA-binding response regulators. Rather, these unusual kinases are often part of atypical regulatory pathways that control changes in gene expression via modulation of protein-protein interactions or transcription anti-termination.
摘要
传感组氨酸激酶调节细胞对环境化学或物理状态变化的适应性反应。HWE/HisKA2家族激酶是组氨酸激酶的一个子集，由催化区域和非催化区域中的独特序列基序定义。最近的晶体结构确定了保守的分子内相互作用，这些相互作用为HWE/HisKA2超家族特有的激酶调节模型提供了信息。新出现的遗传、生化和基因组数据表明，与典型的组氨酸激酶不同，HWE/HisKA2激酶通常不通过经典的DNA结合反应调节因子进行信号传导。相反，这些不同寻常的激酶通常是不典型调节途径的一部分，通过调节蛋白质-蛋白质相互作用或转录抗终止来控制基因表达的变化。
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