Gerrard J M, Stoddard S F, Shapiro R S, Coccia P F, Ramsay N K, Nesbit M E, Rao G H, Krivit W, White J G
Br J Haematol. 1978 Dec;40(4):597-607. doi: 10.1111/j.1365-2141.1978.tb05836.x.
Platelet function was evaluated in eight patients with chronic granulocytic leukaemia (CGL), seven Ph1 positive and one Ph1 negative. Seven of the eight patients' platelets had an absence of the second wave of adrenaline induced aggregation on at least one occasion, while five had impaired collagen aggregation. The platelets of all seven patients with abnormal responses to adrenaline, aggregated with arachidonic acid, thus ruling out a cyclo-oxygenase deficiency. A marked decrease in the ADP, serotonin, and dense body content of platelets was found in all five patients evaluated. Mixtures of CGL patient platelets with platelets from normal donors who had ingested aspirin gave a normal biphasic response to adrenaline. Normal release of the storage pool contents from aspirin treated platelets was shown by stirring a mixture of CGL platelets and 14C-serotonin labelled aspirin treated platelets with adrenaline. The CGL platelets alone or in the mixture produced malondialdehyde in response to adrenaline. These experimental results suggest that CGL platelets have a storage pool deficiency but can synthesize prostaglandins and thromboxanes in response to arachidonic acid and adrenaline.
对8例慢性粒细胞白血病（CGL）患者的血小板功能进行了评估，其中7例Ph1阳性，1例Ph1阴性。8例患者中有7例的血小板至少在一次检测中缺乏肾上腺素诱导的第二波聚集，而5例的胶原聚集受损。所有7例对肾上腺素反应异常的患者的血小板与花生四烯酸发生聚集，从而排除了环氧化酶缺乏。在所有接受评估的5例患者中，均发现血小板的二磷酸腺苷（ADP）、5-羟色胺和致密体含量显著降低。将CGL患者的血小板与摄入阿司匹林的正常供者的血小板混合后，对肾上腺素产生了正常的双相反应。通过用肾上腺素搅拌CGL血小板和14C-5-羟色胺标记的阿司匹林处理的血小板的混合物，显示了阿司匹林处理的血小板储存池内容物的正常释放。单独的CGL血小板或混合物中的CGL血小板在受到肾上腺素刺激时会产生丙二醛。这些实验结果表明，CGL血小板存在储存池缺陷，但能对花生四烯酸和肾上腺素作出反应合成前列腺素和血栓素。
