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Oncoimmunology. 2016 Feb 18;6(1):e1132137. doi: 10.1080/2162402X.2015.1132137. eCollection 2017.
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本文引用的文献

1
Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota.通过CTLA-4阻断进行的抗癌免疫疗法依赖于肠道微生物群。
Science. 2015 Nov 27;350(6264):1079-84. doi: 10.1126/science.aad1329. Epub 2015 Nov 5.
2
Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy.共生双歧杆菌可促进抗肿瘤免疫并增强抗程序性死亡受体配体1（PD-L1）的疗效。
Science. 2015 Nov 27;350(6264):1084-9. doi: 10.1126/science.aac4255. Epub 2015 Nov 5.
3
Cancer and the gut microbiota: an unexpected link.癌症与肠道微生物群：一个意想不到的联系。
Sci Transl Med. 2015 Jan 21;7(271):271ps1. doi: 10.1126/scitranslmed.3010473.
4
Plasmacytoid dendritic cells mediate anti-inflammatory responses to a gut commensal molecule via both innate and adaptive mechanisms.浆细胞样树突状细胞通过先天和适应性机制介导对肠道共生分子的抗炎反应。
Cell Host Microbe. 2014 Apr 9;15(4):413-23. doi: 10.1016/j.chom.2014.03.006.
5
The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide.肠道微生物群调节环磷酰胺的抗癌免疫作用。
Science. 2013 Nov 22;342(6161):971-6. doi: 10.1126/science.1240537.
6
Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment.共生菌通过调节肿瘤微环境来控制癌症对治疗的反应。
Science. 2013 Nov 22;342(6161):967-70. doi: 10.1126/science.1240527.
7
Improved survival with ipilimumab in patients with metastatic melanoma.Ipilimumab 改善转移性黑色素瘤患者的生存。
N Engl J Med. 2010 Aug 19;363(8):711-23. doi: 10.1056/NEJMoa1003466. Epub 2010 Jun 5.
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A new vision of immunity: homeostasis of the superorganism.一种新的免疫观：超有机体的内稳态。
Mucosal Immunol. 2010 Sep;3(5):450-60. doi: 10.1038/mi.2010.20. Epub 2010 May 5.
9
Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4.细胞毒性T淋巴细胞相关抗原4抗体阻断后癌症患者的小肠结肠炎
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通过调控肠道微生物群增强免疫检查点阻断疗法的临床覆盖范围和抗癌疗效。

Enhancing the clinical coverage and anticancer efficacy of immune checkpoint blockade through manipulation of the gut microbiota.

作者信息

Pitt Jonathan M, Vétizou Marie, Gomperts Boneca Ivo, Lepage Patricia, Chamaillard Mathias, Zitvogel Laurence

机构信息

Institut de Cancérologie Gustave Roussy Cancer Campus (GRCC), Villejuif, France; INSERM Unit U1015, Villejuif, France; Faculté de Médecine, Université Paris Sud, Université Paris-Saclay, Le Kremlin Bicêtre, France.

Institut Pasteur, Unit of Biology and Genetics of the Bacterial Cell Wall, Paris, France; INSERM, Equipe Avenir, Paris, France.

出版信息

Oncoimmunology. 2016 Feb 18;6(1):e1132137. doi: 10.1080/2162402X.2015.1132137. eCollection 2017.

DOI:10.1080/2162402X.2015.1132137
PMID:28197360
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5283646/
Abstract

Although anticancer therapy with immune checkpoint blockers has seen unprecedented success, it fails to control neoplasia in most patients and often causes immune-related adverse events (irAEs). Our recent research shows the immunostimulatory and antitumor effects of CTLA-4 blockade depend on distinct species of the gut microbiota, signifying novel approaches to improve such immunotherapies.

摘要

尽管免疫检查点阻断剂的抗癌治疗取得了前所未有的成功，但它在大多数患者中无法控制肿瘤形成，并且常常引发免疫相关不良事件（irAE）。我们最近的研究表明，CTLA-4阻断的免疫刺激和抗肿瘤作用取决于肠道微生物群的不同种类，这意味着有新的方法来改进此类免疫疗法。