Catron P W, Thomas L B, McDermott J J, Smallridge R C, Lake C R, Kinzer C, Chernow B, Flynn E T
Undersea Biomed Res. 1987 Jul;14(4):331-41.
Changes in plasma hormone levels were studied in anesthetized dogs during decompression sickness. Hormone levels were measured in 4 groups: control (no dive, n = 9); air group (air dive, ventilated with air postdive, n = 6); helium-oxygen (He-O2) group (air dive, ventilation changed to He-O2 at 30 min postdive, n = 9); nonsurvivor group (air dive, died within 30 min postdive, n = 9). Dived animals were subjected to repetitive dives until pulmonary artery pressure doubled. Plasma epinephrine (Epi) and norepinephrine (NE) concentrations rapidly increased postdive in all animals. Serum angiotensin-converting enzyme (ACE) activity increased postdive in the He-O2 group only, and these increases were small. Diving did not alter serum concentrations of cortisol, thyroxine (T4), or triiodothyronine (T3); however, T4 and T3 fell in all animals, probably as a consequence of anesthesia. He-O2 breathing did not affect concentrations of Epi, NE, cortisol, T4, T3, or serum ACE activity.
在减压病过程中，对麻醉犬的血浆激素水平变化进行了研究。在4组中测量了激素水平：对照组（未潜水，n = 9）；空气组（空气潜水，潜水后用空气通气，n = 6）；氦氧（He - O2）组（空气潜水，潜水后30分钟通气改为He - O2，n = 9）；非存活组（空气潜水，潜水后30分钟内死亡，n = 9）。对潜水动物进行重复潜水，直到肺动脉压加倍。所有动物潜水后血浆肾上腺素（Epi）和去甲肾上腺素（NE）浓度迅速升高。血清血管紧张素转换酶（ACE）活性仅在He - O2组潜水后升高，且升高幅度较小。潜水未改变皮质醇、甲状腺素（T4）或三碘甲状腺原氨酸（T3）的血清浓度；然而，所有动物的T4和T3均下降，可能是麻醉的结果。He - O2呼吸不影响Epi、NE、皮质醇、T4、T3或血清ACE活性的浓度。
