Ito M, Sekine I, Kummerow F A
Acta Pathol Jpn. 1987 Jun;37(6):955-64. doi: 10.1111/j.1440-1827.1987.tb00445.x.
The effects of magnesium (Mg) supplement on coronary arteries of 61 swine, fed various levels of vitamin D3 (VD3), were studied by light and electron microscopy. High frequencies of smooth muscle cell degeneration were observed in groups of swine fed various levels of excess VD3. Swine fed moderately excessive level of VD3 with a basal level of Mg displayed great incidence and magnitude of intimal thickening, while swine fed the same level of VD3 with supplementary Mg sustained only mild intimal thickening. In groups of swine fed high levels of VD3, the prevention of calcification and smooth muscle cell degeneration was observed as a supplementary Mg effect. Plasma analyses indicated that supplementary Mg with excess VD3 increased cholesterol levels but decreased arterial damage. It is concluded that the dietary Mg supplement prevents coronary atherosclerosis induced by hypervitaminosis D.
通过光学显微镜和电子显微镜研究了补充镁（Mg）对61头喂食不同水平维生素D3（VD3）的猪冠状动脉的影响。在喂食不同过量水平VD3的猪群中观察到平滑肌细胞变性的高频率。喂食中度过量VD3和基础水平Mg的猪内膜增厚的发生率和程度较大，而喂食相同水平VD3并补充Mg的猪仅出现轻度内膜增厚。在喂食高水平VD3的猪群中，观察到补充Mg可预防钙化和平滑肌细胞变性。血浆分析表明，补充Mg与过量VD3会增加胆固醇水平，但会减少动脉损伤。得出的结论是，饮食中补充Mg可预防维生素D过多症引起的冠状动脉粥样硬化。
