Ito M, Toda T, Kummerow F A, Nishimori I
Acta Pathol Jpn. 1986 Feb;36(2):225-34. doi: 10.1111/j.1440-1827.1986.tb01475.x.
The effects of magnesium (Mg) deficiency on the coronary arteries of 27 Yorkshire swine were studied by light and electron microscopy. The experimental animals were divided into 4 groups which received the following supplements: Group I, basal ration with adequate Mg (540 mg/kg diet), Group II, basal ration with insufficient Mg (270 mg/kg diet) Group III, 10% milk powder with adequate Mg (540 mg/kg diet), Group IV, 10% milk powder with insufficient Mg (270 mg/kg diet). Serum analysis indicated that dietary low Mg supplementation decreased cholesterol levels and increased phospholipid concentrations significantly. The highest magnitude and incidence of intimal thickening were observed in the coronary arteries of Group IV (p less than 0.003). No significant intimal thickening was detected in any of the other groups. Ultrastructural studies revealed a greater frequency of degenerated cells in Group III and IV (p less than 0.01). Numerous calcifications were observed in only Group IV. These data suggest that moderate Mg deficiency can promote atherosclerosis in combination with some atherogenic diet, and that the presence of smooth muscle cell degeneration is important in order for a magnesium deficiency to exert an effect on the coronary artery of swine.
通过光学显微镜和电子显微镜研究了镁（Mg）缺乏对27只约克郡猪冠状动脉的影响。将实验动物分为4组，分别给予以下补充剂：第一组，含适量镁（540毫克/千克日粮）的基础日粮；第二组，含镁不足（270毫克/千克日粮）的基础日粮；第三组，含适量镁（540毫克/千克日粮）的10%奶粉；第四组，含镁不足（270毫克/千克日粮）的10%奶粉。血清分析表明，日粮中低镁补充显著降低了胆固醇水平并增加了磷脂浓度。在第四组的冠状动脉中观察到内膜增厚的程度和发生率最高（p小于0.003）。在其他任何组中均未检测到明显的内膜增厚。超微结构研究显示，第三组和第四组中退化细胞的频率更高（p小于0.01）。仅在第四组中观察到大量钙化。这些数据表明，中度镁缺乏与某些致动脉粥样硬化饮食相结合可促进动脉粥样硬化，并且平滑肌细胞退化的存在对于镁缺乏对猪冠状动脉产生影响很重要。
