Santini D, Bazzocchi F, Mazzoleni G, Ricci M, Viti G, Marrano D, Martinelli G
Acta Pathol Microbiol Immunol Scand A. 1987 Sep;95(5):225-31. doi: 10.1111/j.1699-0463.1987.tb00035_95a.x.
A pathological and histochemical study on the presence of signet-ring cells (SRC) in 108 advanced gastric cancer (AGC) has been evaluated. According to Laurén's classification, 59 were of intestinal (I) and 49 of diffuse (D) type. The amount of SRC seems to be a prognostic parameter in D-carcinoma: the 5-year survival rate was 49% and 22% in cases with 1-24% and 75-100% SRC, respectively. Histochemically, in our series of SRC D-carcinoma the quality of mucin secretion of SRC closely resembled the goblet cells of intestinal metaplasia. The histogenetic origin of D-gastric carcinoma was discussed.
对108例进展期胃癌（AGC）中印戒细胞（SRC）的存在情况进行了病理学和组织化学研究。根据劳伦分类，59例为肠型（I），49例为弥漫型（D）。SRC的数量似乎是D型癌的一个预后参数：SRC占1 - 24%和75 - 100%的病例，其5年生存率分别为49%和22%。组织化学研究表明，在我们的SRC D型癌系列中，SRC的粘蛋白分泌性质与肠化生的杯状细胞非常相似。本文还讨论了D型胃癌的组织发生学起源。
