Li W J, Steck P, Bowen J M, Chan J C
Biochem Biophys Res Commun. 1987 Aug 31;147(1):513-8. doi: 10.1016/s0006-291x(87)80151-1.
In this report, data are presented to show that transformation-associated proteins (TAP) secreted from the transformed 6M2 cells have mitogenic activities in the stimulation of DNA synthesis and proliferation of normal rat kidney (NRK-2) cells and of nonpermissively grown 6M2 cells. TAP also bound specifically to NRK-2 cells with a binding dissociation constant (Kd) of 1.4 pM. Approximately 2 X 10(5) binding sites per cell were found. Therefore, TAP may represent a set of virally-induced growth stimulatory factors.
在本报告中，所呈现的数据表明，从转化的6M2细胞分泌的转化相关蛋白（TAP）在刺激正常大鼠肾（NRK - 2）细胞以及非允许生长的6M2细胞的DNA合成和增殖方面具有促有丝分裂活性。TAP还以1.4 pM的结合解离常数（Kd）特异性结合NRK - 2细胞。每个细胞大约发现2×10⁵个结合位点。因此，TAP可能代表一组病毒诱导的生长刺激因子。
