Cardoso Mariana F do C, Gomes Ana T P C, Moreira Caroline Dos S, Simões Mário M Q, Neves Maria G P M S, da Rocha David R, da Silva Fernando de C, Moreirinha Catarina, Almeida Adelaide, Ferreira Vitor F, Cavaleiro José A S
Department of Chemistry and QOPNA, University of Aveiro, Aveiro 3810-193, Portugal.
Departamento de Química Orgânica, Instituto de Química, Universidade Federal Fluminense, Niterói 24020-150, RJ, Brazil.
Molecules. 2017 Feb 16;22(2):302. doi: 10.3390/molecules22020302.
New sulfonyl-lapachones were efficiently obtained through the catalytic oxidation of arylthio- and cyclohexylthio-lapachone derivatives with hydrogen peroxide in the presence of a Mn(III) porphyrin complex. The antibacterial activities of the non-oxidized and oxidized lapachone derivatives against the Gram-negative bacteria and the Gram-positive bacteria were evaluated after their incorporation into polyvinylpyrrolidone (PVP) micelles. The obtained results show that the PVP-formulations of the lapachones - and of the sulfonyl-lapachones and reduced the growth of .
通过在锰（III）卟啉配合物存在下用过氧化氢催化氧化芳硫基和环己硫基拉帕醌衍生物，高效地获得了新型磺酰基拉帕醌。将未氧化和氧化的拉帕醌衍生物掺入聚乙烯吡咯烷酮（PVP）胶束后，评估了它们对革兰氏阴性菌和革兰氏阳性菌的抗菌活性。所得结果表明，拉帕醌以及磺酰基拉帕醌的PVP制剂减少了[具体细菌名称未给出]的生长。
