Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, Raleigh, NC 27695, USA.
Department of Biomedical Engineering, Center for Genomic & Computational Biology, Duke University, Durham, NC 27708, USA; Department of Orthopaedic Surgery, Duke University Medical Center, Durham, NC 27708, USA.
Mol Cell. 2017 Feb 16;65(4):582-584. doi: 10.1016/j.molcel.2017.02.002.
In this issue of Molecular Cell, Smargon et al. (2017) unearth Cas13b from type VI-B CRISPR-Cas immune systems and characterize its RNA-guided, RNA-targeting activity, including regulation by the novel co-factors Csx27 and Csx28, as well as non-specific collateral RNA damage.
在本期《分子细胞》中，Smargon 等人（2017）从 VI-B 型 CRISPR-Cas 免疫系统中挖掘出 Cas13b，并对其 RNA 指导的、靶向 RNA 的活性进行了表征，包括由新型共因子 Csx27 和 Csx28 以及非特异性的 RNA 损伤的调控。
