HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
BMC Biol. 2018 Mar 19;16(1):32. doi: 10.1186/s12915-018-0504-9.
A molecular arms race is progressively being unveiled between prokaryotes and viruses. Prokaryotes utilize CRISPR-mediated adaptive immune systems to kill the invading phages and mobile genetic elements, and in turn, the viruses evolve diverse anti-CRISPR proteins to fight back. The structures of several anti-CRISPR proteins have now been reported, and here we discuss their structural features, with a particular emphasis on topology, to discover their similarities and differences. We summarize the CRISPR-Cas inhibition mechanisms of these anti-CRISPR proteins in their structural context. Considering anti-CRISPRs in this way will provide important clues for studying their origin and evolution.
原核生物与病毒之间正在进行一场分子军备竞赛。原核生物利用 CRISPR 介导的适应性免疫系统来杀死入侵的噬菌体和移动遗传元件，而病毒则进化出多种抗 CRISPR 蛋白来进行反击。现在已经报道了几种抗 CRISPR 蛋白的结构，在这里我们讨论它们的结构特征，特别强调拓扑结构，以发现它们的相似和不同之处。我们总结了这些抗 CRISPR 蛋白在结构背景下对 CRISPR-Cas 抑制机制的作用。以这种方式考虑抗 CRISPR 蛋白将为研究它们的起源和进化提供重要线索。
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