基于 CRISPR 的技术：RNA 靶向系统的影响。
CRISPR-Based Technologies: Impact of RNA-Targeting Systems.
机构信息
Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA; Department of Genetics, University of Georgia, Athens, GA 30602, USA; Department of Microbiology, University of Georgia, Athens, GA 30602, USA.
出版信息
Mol Cell. 2018 Nov 1;72(3):404-412. doi: 10.1016/j.molcel.2018.09.018.
DNA-targeting CRISPR-Cas systems, such as those employing the RNA-guided Cas9 or Cas12 endonucleases, have revolutionized our ability to predictably edit genomes and control gene expression. Here, I summarize information on RNA-targeting CRISPR-Cas systems and describe recent advances in converting them into powerful and programmable RNA-binding and cleavage tools with a wide range of novel and important biotechnological and biomedical applications.
DNA 靶向 CRISPR-Cas 系统，如使用 RNA 指导的 Cas9 或 Cas12 内切酶的系统，彻底改变了我们可预测地编辑基因组和控制基因表达的能力。在这里，我总结了 RNA 靶向 CRISPR-Cas 系统的信息，并描述了最近将其转化为强大且可编程的 RNA 结合和切割工具的进展，这些工具具有广泛的新型和重要的生物技术和生物医学应用。
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