• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

跳跃物种——冠状病毒持续存在和生存的一种机制。

Jumping species-a mechanism for coronavirus persistence and survival.

作者信息

Menachery Vineet D, Graham Rachel L, Baric Ralph S

机构信息

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.

出版信息

Curr Opin Virol. 2017 Apr;23:1-7. doi: 10.1016/j.coviro.2017.01.002. Epub 2017 Mar 31.

DOI:10.1016/j.coviro.2017.01.002
PMID:28214731
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5474123/
Abstract

Zoonotic transmission of novel viruses represents a significant threat to global public health and is fueled by globalization, the loss of natural habitats, and exposure to new hosts. For coronaviruses (CoVs), broad diversity exists within bat populations and uniquely positions them to seed future emergence events. In this review, we explore the host and viral dynamics that shape these CoV populations for survival, amplification, and possible emergence in novel hosts.

摘要

新型病毒的人畜共患传播对全球公共卫生构成重大威胁，全球化、自然栖息地丧失以及接触新宿主加剧了这一威胁。对于冠状病毒（CoV）而言，蝙蝠种群中存在广泛的多样性，这使其成为未来新疫情出现的独特源头。在本综述中，我们探讨了塑造这些冠状病毒种群以实现生存、扩增并可能在新宿主中出现的宿主和病毒动态。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2cd1/7102682/4221de40364f/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2cd1/7102682/c0a0011a2dc0/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2cd1/7102682/4c764feb45f8/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2cd1/7102682/4221de40364f/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2cd1/7102682/c0a0011a2dc0/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2cd1/7102682/4c764feb45f8/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2cd1/7102682/4221de40364f/gr3_lrg.jpg

相似文献

1
Jumping species-a mechanism for coronavirus persistence and survival.跳跃物种——冠状病毒持续存在和生存的一种机制。
Curr Opin Virol. 2017 Apr;23:1-7. doi: 10.1016/j.coviro.2017.01.002. Epub 2017 Mar 31.
2
Coronavirus and paramyxovirus in bats from Northwest Italy.意大利西北部蝙蝠体内的冠状病毒和副粘病毒。
BMC Vet Res. 2017 Dec 22;13(1):396. doi: 10.1186/s12917-017-1307-x.
3
Wide Diversity of Coronaviruses in Frugivorous and Insectivorous Bat Species: A Pilot Study in Guinea, West Africa.果蝠和食虫蝙蝠物种中冠状病毒的广泛多样性：来自西非几内亚的初步研究。
Viruses. 2020 Aug 5;12(8):855. doi: 10.3390/v12080855.
4
The zoonotic potential of bat-borne coronaviruses.蝙蝠携带的冠状病毒的人畜共患病潜力。
Emerg Top Life Sci. 2020 Dec 11;4(4):353-369. doi: 10.1042/ETLS20200097.
5
In-silico nucleotide and protein analyses of S-gene region in selected zoonotic coronaviruses reveal conserved domains and evolutionary emergence with trajectory course of viral entry from SARS-CoV-2 genomic data.对选定的人畜共患冠状病毒 S 基因区域进行的核苷酸和蛋白质计算机分析揭示了保守结构域，并从 SARS-CoV-2 基因组数据中推断出病毒进入的轨迹和进化起源。
Pan Afr Med J. 2020 Nov 30;37:285. doi: 10.11604/pamj.2020.37.285.24663. eCollection 2020.
6
Surveillance of Bat Coronaviruses in Kenya Identifies Relatives of Human Coronaviruses NL63 and 229E and Their Recombination History.肯尼亚蝙蝠冠状病毒监测发现人类冠状病毒NL63和229E的亲属及其重组历史。
J Virol. 2017 Feb 14;91(5). doi: 10.1128/JVI.01953-16. Print 2017 Mar 1.
7
Origin and cross-species transmission of bat coronaviruses in China.中国蝙蝠冠状病毒的起源与跨物种传播。
Nat Commun. 2020 Aug 25;11(1):4235. doi: 10.1038/s41467-020-17687-3.
8
Ecology, evolution and classification of bat coronaviruses in the aftermath of SARS.SARS 后蝙蝠冠状病毒的生态学、进化和分类。
Antiviral Res. 2014 Jan;101:45-56. doi: 10.1016/j.antiviral.2013.10.013. Epub 2013 Oct 31.
9
Cross host transmission in the emergence of MERS coronavirus.中东呼吸综合征冠状病毒出现过程中的跨宿主传播
Curr Opin Virol. 2016 Feb;16:55-62. doi: 10.1016/j.coviro.2016.01.004. Epub 2016 Jan 29.
10
Clinical and molecular aspects of veterinary coronaviruses.兽医冠状病毒的临床和分子方面。
Virus Res. 2021 May;297:198382. doi: 10.1016/j.virusres.2021.198382. Epub 2021 Mar 8.

引用本文的文献

1
SARS-CoV-2 RNA-binding protein suppresses extracellular miRNA release.严重急性呼吸综合征冠状病毒2（SARS-CoV-2）RNA结合蛋白抑制细胞外微小RNA（miRNA）释放。
RNA Biol. 2025 Dec;22(1):1-17. doi: 10.1080/15476286.2025.2527494. Epub 2025 Jul 7.
2
Dipeptidyl peptidase 4 interacts with porcine coronavirus PHEV spikes and mediates host range expansion.二肽基肽酶 4 与猪传染性胃肠炎病毒刺突蛋白相互作用并介导宿主范围扩展。
J Virol. 2024 Jul 23;98(7):e0075324. doi: 10.1128/jvi.00753-24. Epub 2024 Jun 3.
3
Proactive vaccination using multiviral Quartet Nanocages to elicit broad anti-coronavirus responses.

本文引用的文献

1
Phenotypic and functional characterization of the major lymphocyte populations in the fruit-eating bat Pteropus alecto.果蝠 Pteropus alecto 主要淋巴细胞群体的表型和功能特征。
Sci Rep. 2016 Nov 24;6:37796. doi: 10.1038/srep37796.
2
Proteolytic processing of Middle East respiratory syndrome coronavirus spikes expands virus tropism.中东呼吸综合征冠状病毒刺突蛋白的蛋白水解加工扩展了病毒嗜性。
Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12262-12267. doi: 10.1073/pnas.1608147113. Epub 2016 Oct 10.
3
Molecular Evolution of Human Coronavirus Genomes.
使用多病毒四联纳米笼进行主动疫苗接种以引发广泛的抗病毒反应。
Nat Nanotechnol. 2024 Aug;19(8):1216-1223. doi: 10.1038/s41565-024-01655-9. Epub 2024 May 6.
4
Corona- and Paramyxoviruses in Bats from Brazil: A Matter of Concern?巴西蝙蝠中的冠状病毒和副粘病毒：值得关注吗？
Animals (Basel). 2023 Dec 26;14(1):88. doi: 10.3390/ani14010088.
5
Simple, Fast and Convenient Magnetic Bead-Based Sample Preparation for Detecting Viruses via Raman-Spectroscopy.基于磁珠的简便、快速、便捷的样本制备方法，用于通过拉曼光谱法检测病毒。
Biosensors (Basel). 2023 May 30;13(6):594. doi: 10.3390/bios13060594.
6
Identification of Evolutionary Trajectories Shared across Human Betacoronaviruses.鉴定人类贝塔冠状病毒之间共享的进化轨迹。
Genome Biol Evol. 2023 Jun 1;15(6). doi: 10.1093/gbe/evad076.
7
Spike-Independent Infection of Human Coronavirus 229E in Bat Cells.人冠状病毒 229E 在蝙蝠细胞中的非依赖性感染。
Microbiol Spectr. 2023 Jun 15;11(3):e0348322. doi: 10.1128/spectrum.03483-22. Epub 2023 May 18.
8
Evaluation of Remdesivir Utilization Pattern in Critically Ill Patients With COVID-19 in Jazan Province.吉赞省新冠肺炎危重症患者中瑞德西韦使用模式的评估
Cureus. 2023 Mar 16;15(3):e36247. doi: 10.7759/cureus.36247. eCollection 2023 Mar.
9
An Overview on Exploitation of Graphene-Based Membranes: From Water Treatment to Medical Industry, Including Recent Fighting against COVID-19.基于石墨烯的膜的应用概述：从水处理到医疗行业，包括近期抗击新冠疫情的情况
Microorganisms. 2023 Jan 25;11(2):310. doi: 10.3390/microorganisms11020310.
10
RNA structure-altering mutations underlying positive selection on Spike protein reveal novel putative signatures to trace crossing host-species barriers in .RNA 结构改变突变是 Spike 蛋白正选择的基础，揭示了追踪跨越宿主物种屏障的新的潜在特征。
RNA Biol. 2022 Jan;19(1):1019-1044. doi: 10.1080/15476286.2022.2115750.
人类冠状病毒基因组的分子进化
Trends Microbiol. 2017 Jan;25(1):35-48. doi: 10.1016/j.tim.2016.09.001. Epub 2016 Oct 19.
4
A Bat-Derived Putative Cross-Family Recombinant Coronavirus with a Reovirus Gene.一种携带呼肠孤病毒基因的源自蝙蝠的假定跨家族重组冠状病毒。
PLoS Pathog. 2016 Sep 27;12(9):e1005883. doi: 10.1371/journal.ppat.1005883. eCollection 2016 Sep.
5
Persistence of Rabies Virus-Neutralizing Antibodies after Vaccination of Rural Population following Vampire Bat Rabies Outbreak in Brazil.巴西吸血蝙蝠狂犬病疫情后农村人口接种疫苗后狂犬病病毒中和抗体的持久性
PLoS Negl Trop Dis. 2016 Sep 21;10(9):e0004920. doi: 10.1371/journal.pntd.0004920. eCollection 2016 Sep.
6
SARS and MERS: recent insights into emerging coronaviruses.严重急性呼吸综合征和中东呼吸综合征：对新型冠状病毒的最新见解
Nat Rev Microbiol. 2016 Aug;14(8):523-34. doi: 10.1038/nrmicro.2016.81. Epub 2016 Jun 27.
7
Characterization of the Antigen Processing Machinery and Endogenous Peptide Presentation of a Bat MHC Class I Molecule.蝙蝠主要组织相容性复合体I类分子的抗原加工机制及内源性肽呈递的特征分析
J Immunol. 2016 Jun 1;196(11):4468-76. doi: 10.4049/jimmunol.1502062. Epub 2016 Apr 27.
8
Bat Severe Acute Respiratory Syndrome-Like Coronavirus WIV1 Encodes an Extra Accessory Protein, ORFX, Involved in Modulation of the Host Immune Response.蝙蝠严重急性呼吸综合征样冠状病毒WIV1编码一种额外的辅助蛋白ORFX，参与宿主免疫反应的调节。
J Virol. 2016 Jun 24;90(14):6573-6582. doi: 10.1128/JVI.03079-15. Print 2016 Jul 15.
9
SARS-like WIV1-CoV poised for human emergence.类似SARS的WIV1冠状病毒随时可能在人类中出现。
Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3048-53. doi: 10.1073/pnas.1517719113. Epub 2016 Mar 14.
10
Coronavirus Host Range Expansion and Middle East Respiratory Syndrome Coronavirus Emergence: Biochemical Mechanisms and Evolutionary Perspectives.冠状病毒宿主范围扩张和中东呼吸综合征冠状病毒出现：生化机制和进化视角。
Annu Rev Virol. 2015 Nov;2(1):95-117. doi: 10.1146/annurev-virology-100114-055029. Epub 2015 Aug 7.