Ho Samuel B, Hovsepians Rita, Gupta Samir
VA San Diego Healthcare System and University of California, 3350 La Jolla Village Drive, San Diego, CA, 92161, USA.
Drugs Aging. 2017 Mar;34(3):163-172. doi: 10.1007/s40266-017-0436-z.
Colonoscopy is an important diagnostic and screening tool for colorectal cancer detection and prevention, and adequate bowel preparation is critical for successful colonoscopy. Complications related to colonoscopy, either directly or indirectly related to the procedure, are increased in elderly patients, and the risks and benefits of colonoscopy procedures need to be carefully considered in these patients. Recent studies have shown that 4 L polyethylene glycol with a split preparation is safe and effective for elderly patients, and is the preferred preparation for patients with medical comorbidities. Preparations containing sodium phosphate are generally not recommended for the elderly because of increased renal complications. In addition, a low-residue diet may aid in tolerance and willingness to undergo the procedure compared with a clear liquid diet, with comparable bowel preparation adequacy. Risk factors for inadequate bowel preparations include poor adherence to split preparation instructions or volume of solution ingested, and certain patient-related medications and comorbidities, such as diabetes, elevated body mass index, and antidepressant or narcotic use. Methods for achieving safe and adequate bowel preparations in the elderly include clear instructions, reminder calls, and case management for potential confounding patient-related factors.
结肠镜检查是结直肠癌检测和预防的重要诊断及筛查工具,充分的肠道准备对于结肠镜检查的成功至关重要。与结肠镜检查直接或间接相关的并发症在老年患者中有所增加,因此在这些患者中需要仔细考虑结肠镜检查的风险和益处。最近的研究表明,4升聚乙二醇分阶段服用对老年患者安全有效,是患有内科合并症患者的首选肠道准备方法。由于肾并发症增加,一般不建议老年患者使用含磷酸钠的肠道准备剂。此外,与清流食相比,低渣饮食可能有助于提高患者对结肠镜检查的耐受性和接受意愿,且肠道准备的充分程度相当。肠道准备不充分的风险因素包括未严格遵循分阶段服用说明或摄入溶液量不足,以及某些与患者相关的药物和合并症,如糖尿病、体重指数升高、使用抗抑郁药或麻醉药等。在老年患者中实现安全且充分的肠道准备的方法包括提供清晰的说明、提醒电话以及对潜在的与患者相关的混杂因素进行病例管理。