FOXP3和RORγt在调节性T细胞和辅助性T细胞17中的功能稳定性及其治疗应用
The Functional Stability of FOXP3 and RORγt in Treg and Th17 and Their Therapeutic Applications.
作者信息
Ren J, Li B
机构信息
Key Laboratory of Molecular Virology and Immunology, CAS Center for Excellence in Molecular Cell Science, Unit of Molecular Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Universities and Colleges Admissions Service, Shanghai, PR China.
Key Laboratory of Molecular Virology and Immunology, CAS Center for Excellence in Molecular Cell Science, Unit of Molecular Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Universities and Colleges Admissions Service, Shanghai, PR China; Shanghai Institute of Immunology, Shanghai JiaoTong University School of Medicine, Shanghai, PR China.
出版信息
Adv Protein Chem Struct Biol. 2017;107:155-189. doi: 10.1016/bs.apcsb.2016.10.002. Epub 2016 Dec 15.
The balance of CD4CD25FOXP3 regulatory T cells (Tregs) and effector T cells plays a key role in maintaining immune homeostasis, while the imbalance of them is related to many inflammatory diseases in both human and mice. Here we discuss about the plasticity of Tregs and Th17 cells, and the related human diseases resulted from the imbalance of them. Further, we will focus on the mechanisms regulating the plasticity between Tregs and Th17 cells and the potential therapeutic strategies by targeting regulators of the expression and activity of FOXP3 and RORγt or regulators of Treg/Th17 balance in autoimmune diseases, allergy, infection, and cancer.
CD4CD25FOXP3调节性T细胞（Tregs）和效应T细胞之间的平衡在维持免疫稳态中起关键作用，而它们之间的失衡与人类和小鼠的许多炎症性疾病有关。在此，我们讨论Tregs和Th17细胞的可塑性，以及由它们失衡导致的相关人类疾病。此外，我们将重点关注调节Tregs和Th17细胞之间可塑性的机制，以及在自身免疫性疾病、过敏、感染和癌症中，通过靶向FOXP3和RORγt表达及活性的调节因子或Treg/Th17平衡的调节因子的潜在治疗策略。
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