Yu Mu-Yuan, Zhao Gao-Ting, Liu Jie-Qing, Khan Afsar, Peng Xing-Rong, Zhou Lin, Dong Jin-Run, Li Hai-Zhou, Qiu Ming-Hua
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; Graduate University of the Chinese Academy of Sciences, Beijing 100049, China; Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, China.
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China.
Phytochemistry. 2017 May;137:148-155. doi: 10.1016/j.phytochem.2017.02.009. Epub 2017 Feb 16.
Twenty withanolides, including previously unknown nicanlodes A-M, were isolated from aerial parts of Nicandra physalodes. Their structural elucidations were unambiguously achieved through interpretation of extensive spectroscopic data (NMR and HRMS) and by comparison with literature data. Nicanlodes A and B have an unusual aromatic amine moiety. The isolated compounds were evaluated for their cytotoxicity against five human cancer cell lines.
从假酸浆的地上部分分离出了20种睡茄内酯，包括此前未知的尼坎洛德A - M。通过对大量光谱数据（核磁共振和高分辨质谱）的解析以及与文献数据对比，明确完成了它们的结构鉴定。尼坎洛德A和B含有不寻常的芳香胺部分。对分离出的化合物针对五种人类癌细胞系的细胞毒性进行了评估。
