Xiao Qin, Wang Cui-Fang, Chen Jun, Lian Chen-Lei, Xu Ying, Xiao Lei, Liu Jie-Qing
School of Biomedical Sciences, Huaqiao University, Quanzhou 362021, China.
College of Oceanology and Food Science, Quanzhou Normal University, Quanzhou 362000, China.
Steroids. 2018 Mar;131:32-36. doi: 10.1016/j.steroids.2018.01.003.
Chemical investigation on ethyl acetate extract of the calyces of Nicandra physaloides resulted in the isolation of three new withanolides named as nicphysatone A (1), nicphysatone B (2), nicphysatone C (3), together with five known withanolides, nic 17 (4), nic 7 (5), nic 2 (6), withahisolide G (7) and nicaphysalin B (8). The structures were determined by comprehensive spectroscopic experiments. The discovery enriched the diversity of natural withanolides and could serve as scaffolds for the synthesis of more potent modified withanolides.
对假酸浆花萼的乙酸乙酯提取物进行化学研究，从中分离出三种新的睡茄内酯，分别命名为假酸浆酮A（1）、假酸浆酮B（2）、假酸浆酮C（3），以及五种已知的睡茄内酯，尼可17（4）、尼可7（5）、尼可2（6）、维沙索内酯G（7）和尼卡酸浆素B（8）。通过全面的光谱实验确定了这些化合物的结构。这一发现丰富了天然睡茄内酯的多样性，并可为合成更有效的修饰睡茄内酯提供骨架。
