以大鼠为动物模型研究新疆紫草对二度烧伤创面的愈合作用。
The healing effect of arnebia euchroma in second degree burn wounds in rat as an animal model.
作者信息
Ashkani-Esfahani S, Imanieh M H, Khoshneviszadeh M, Meshksar A, Noorafshan A, Geramizadeh B, Ebrahimi S, Handjani F, Tanideh N
机构信息
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
出版信息
Iran Red Crescent Med J. 2012 Feb;14(2):70-4. Epub 2012 Feb 1.
BACKGROUND
Finding more efficient agents with fewer side effects for treatment of burns has always been a concern for researchers. Silver sulfadiazine (SSD), apparently due to its antimicrobial effect, is still one of the most common prescribed agents. Previous studies suggested that Arnebia euchroma (AE) has shown antimicrobial and anti-inflammatory activities. This study investigates the healing effect of AE extract in comparison with SSD in second degree burn wounds.
METHODS
Fort eight female Wistar rats (220±20 g) were divided into four groups. Standard second degree burn wounds were induced on the back of their necks. One group was treated with SSD; two groups were treated with AE cream at concentrations of 10% (AE10) and 20% (AE20) and the control group which received no treatment. The duration of treatment was 28 days.
RESULTS
This study revealed that AE and SSD noticeably improved re-epithelization, fibroblasts proliferation, and collagen bundle synthesis and had a noticeable anti-inflammatory effect compared with the control group.
CONCLUSION
Results of the present study revealed that Arnebia euchroma herbal extract was an effective treatment for second degree burn wounds when compared with SSD.
背景
寻找更高效且副作用更少的烧伤治疗药物一直是研究人员关注的问题。磺胺嘧啶银（SSD）显然因其抗菌作用，仍是最常用的处方药之一。先前的研究表明，新疆紫草（AE）具有抗菌和抗炎活性。本研究比较了AE提取物与SSD对二度烧伤创面的愈合效果。
方法
将48只雌性Wistar大鼠（220±20克）分为四组。在它们的颈部背面诱导形成标准的二度烧伤创面。一组用SSD治疗；两组分别用浓度为10%（AE10）和20%（AE20）的AE乳膏治疗，对照组不进行治疗。治疗持续28天。
结果
本研究表明，与对照组相比，AE和SSD显著促进了上皮再形成、成纤维细胞增殖以及胶原束合成，且具有显著的抗炎作用。
结论
本研究结果表明，与SSD相比，新疆紫草药提取物是治疗二度烧伤创面的有效药物。
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