Samedi Veronica, Field Stephen K, Al Awad Essa, Ratcliffe Gregory, Yusuf Kamran
Department of Pediatrics, Section of Neonatology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Department of Medicine, Section of Respiratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
BMC Pregnancy Childbirth. 2017 Feb 20;17(1):66. doi: 10.1186/s12884-017-1256-1.
Congenital tuberculosis is a rare manifestation of tuberculosis. The diagnosis is often delayed, especially in preterm neonates because of the non-specific clinical presentation and the lack of awareness of maternal disease prior to pregnancy.
We report a case of congenital tuberculosis in an infant born at 24 weeks of gestation to a mother who presented with uncontrolled seizures during preterm labor. Maternal diagnosis was initially made by placental pathology, and later confirmed by isolation of Mycobacterium tuberculosis in urine, gastric aspirates and sputum. Full screening was performed on the newborn infant, and both mother and infant were successfully treated for tuberculosis with a four drug regimen.
Pregnancy can exacerbate latent tuberculosis and women originating from endemic areas are especially susceptible. The best way to prevent congenital tuberculosis is to have a high index of suspicion and identify and treat tuberculosis in pregnant women.
先天性结核病是结核病的一种罕见表现形式。诊断往往会延迟，尤其是在早产儿中，这是由于临床表现不具特异性以及孕期前对母体疾病缺乏认知。
我们报告一例先天性结核病病例，患儿孕24周出生，其母亲在早产时出现癫痫发作且无法控制。母亲的诊断最初通过胎盘病理学做出，后来通过尿液、胃吸出物和痰液中结核分枝杆菌的分离得以确诊。对新生儿进行了全面筛查，母亲和婴儿均采用四联药物疗法成功治愈结核病。
妊娠可使潜伏性结核病加重，来自流行地区的女性尤其易感。预防先天性结核病的最佳方法是保持高度怀疑指数，并识别和治疗孕妇的结核病。
