妊娠合并结核病。
Tuberculosis in pregnancy.
机构信息
Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong SAR, China.
Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong SAR, China.
出版信息
Best Pract Res Clin Obstet Gynaecol. 2022 Dec;85(Pt A):34-44. doi: 10.1016/j.bpobgyn.2022.07.006. Epub 2022 Jul 31.
Due to COVID-19 pandemic, the latest progress of the End Tuberculosis (TB) Strategy was far from optimal and services for TB needs to be quickly restored. Pregnancy is a unique opportunity to screen and manage TB, and it is an essential step in TB eradication. Early diagnosis and treatment for active disease can reduce maternal and neonatal morbidities and mortality. The more widespread utilization of newer rapid molecular assays with drug-susceptibility testing has significantly shortened the diagnostic process for active TB disease. First-line anti-TB drugs are proven to be safe in pregnancy. Management of latent TB infection (LTBI) during pregnancy is controversial, but puerperium is a period of increased susceptibility to progress to active disease. Extrapulmonary TB (EPTB), multidrug-resistant TB (MDR-TB) and HIV co-infection remain significant issues surrounding TB management during pregnancy and often require input from a multidisciplinary team including TB experts.
由于 COVID-19 大流行，终结结核病（TB）策略的最新进展远非理想，结核病服务需要迅速恢复。妊娠是筛查和管理结核病的独特机会，也是消除结核病的重要步骤。早期诊断和治疗活动性疾病可降低母婴发病率和死亡率。更广泛地利用具有药敏检测的新型快速分子检测方法，显著缩短了活动性结核病的诊断过程。一线抗结核药物已被证明在妊娠期间是安全的。妊娠期间潜伏性结核感染（LTBI）的管理存在争议，但产褥期是进展为活动性疾病的易感性增加的时期。肺外结核病（EPTB）、耐多药结核病（MDR-TB）和 HIV 合并感染仍然是妊娠期间结核病管理的重大问题，通常需要包括结核病专家在内的多学科团队的参与。
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