Johns Hopkins University-Byramjee Jeejeebhoy Medical College Clinical Trials Unit, Pune, India.
Johns Hopkins University-Byramjee Jeejeebhoy Medical College Clinical Trials Unit, Pune, India, Johns Hopkins School of Medicine, Baltimore, Maryland.
Int J Tuberc Lung Dis. 2019 Jan 1;23(1):19-25. doi: 10.5588/ijtld.18.0337.
Pregnancy is associated with insulin resistance similar to that found in type 2 diabetes mellitus (DM). The prevalence of gestational diabetes mellitus (GDM) in key tuberculosis (TB) endemic countries, such as India and China, has been increasing rapidly in the last decade and may be higher in human immunodeficiency virus (HIV) infected women. Pregnancy is also an independent risk factor for developing active TB; however, little is known about the interaction of GDM, HIV and TB. We review the epidemiology and immunology of GDM, and significant research gaps in understanding the interactions between GDM, pregnancy, and TB in women living with and those without HIV.
妊娠与胰岛素抵抗有关，类似于 2 型糖尿病（DM）。在印度和中国等主要结核病（TB）流行国家，妊娠糖尿病（GDM）的患病率在过去十年中迅速增加，而在感染人类免疫缺陷病毒（HIV）的妇女中可能更高。妊娠也是发生活动性结核病的独立危险因素；然而，对于 GDM、HIV 和 TB 之间的相互作用知之甚少。我们综述了 GDM 的流行病学和免疫学，以及在了解 HIV 感染者和非感染者中 GDM、妊娠和 TB 之间相互作用方面存在的重大研究空白。
