Chen Jie-Yu, Yu Ke-Qiang, Sun Xiao-Min, Chen Ze-Wei, Kuang Liu-Yan, Ji Yan-Zhao, Zhao Xiao-Shan, Luo Ren
1School of Traditional Chinese Medicine; 2Department of Traditional Chinese Medicine, Nanfang Hospital. E-mail:
Nan Fang Yi Ke Da Xue Xue Bao. 2016 Feb 20;37(2):184-191. doi: 10.3969/j.issn.1673-4254.2017.02.07.
To determine evaluate the effect of health-promoting lifestyle on the outcomes of suboptimal health status (SHS).
A prospective population cohort was conducted by consecutively enrolling 5676 college students who took routine health examination from March to May 2013. The participants were assessed for baseline health status and lifestyle and 2972 participants with SHS were followed up for 1.5 years. Exposure was defined as an unhealthy lifestyle. The health-promoting lifestyle was assessed via the Health-promoting Lifestyle Profile (HPLP-II). SHS was evaluated using the medical examination report and Sub-health Measurement Scale V1.0 (SHMS V1.0).
Among the 2972 students with SHS, 422 showed recovery of the healthy status at 1.5 year follow-up, 579 showed progression into disease conditions, and 1971 remained in SHS. The participants with recovered health status presented with significant increase of SHMS V1.0 scores by 8.75∓6.95 points compared to the baseline assessment (t=-2.14, P=0.000) in physiological, psychological and social dimensions; they also showed a marked improvement of HPLP-II scores by 14.73 points in 6 dimensions (t=-15.34, P=0.000). Multivariable regression analyses with adjusted demographic variables revealed a significant association between health status and health-promoting lifestyle (P<0.05). Compared with a healthy lifestyle (minimal exposure), a 'poor' lifestyle (the highest level of exposure) was associated with a 30 times higher risk of developing SHS (OR: 30.598, 95% CI: 3.928-238.331), while a 'moderate' lifestyle (a relatively high-level exposure) had a 24 times higher risk of SHS (OR: 23.988, 95%CI: 14.695-39.158), and a suboptimal lifestyle had a nearly 4 times higher risk of SHS (OR: 4.306, 95%CI: 2.767-6.702).
s SHS may evolve into either a healthy or a disease condition. A unhealthy lifestyle is the important risk factor contributing to the progression of SHS into a disease condition, suggesting the importance of intervention of unhealthy lifestyles in promoting good health.
确定并评估健康促进生活方式对亚健康状态（SHS）结局的影响。
通过连续招募2013年3月至5月进行常规健康检查的5676名大学生开展一项前瞻性人群队列研究。对参与者进行基线健康状况和生活方式评估，对2972名亚健康状态的参与者进行了1.5年的随访。暴露被定义为不健康的生活方式。通过健康促进生活方式量表（HPLP-II）评估健康促进生活方式。使用体检报告和亚健康测评量表V1.0（SHMS V1.0）评估亚健康状态。
在2972名亚健康状态的学生中，422名在1.5年随访时恢复到健康状态，579名进展为疾病状态，1971名仍处于亚健康状态。恢复到健康状态的参与者在生理、心理和社会维度的SHMS V1.0得分相比基线评估显著增加8.75±6.95分（t=-2.14，P=0.000）；他们在6个维度的HPLP-II得分也显著提高了14.73分（t=-15.34，P=0.000）。对调整后的人口统计学变量进行多变量回归分析显示，健康状况与健康促进生活方式之间存在显著关联（P<0.05）。与健康生活方式（最低暴露水平）相比，“差”的生活方式（最高暴露水平）发生亚健康状态的风险高30倍（OR：30.598，95%CI：3.928-238.331），而“中等”生活方式（相对高水平暴露）发生亚健康状态的风险高24倍（OR：23.988，95%CI：14.695-39.158）, 次优生活方式发生亚健康状态的风险高近4倍（OR：4.306，95%CI：2.767-6.702）。
亚健康状态可能演变为健康状态或疾病状态。不健康的生活方式是导致亚健康状态进展为疾病状态的重要危险因素，提示干预不健康生活方式对促进健康的重要性。
