Valkanova Vyara, Ebmeier Klaus P
Department of Psychiatry, University of Oxford, UK.
Gait Posture. 2017 Mar;53:215-223. doi: 10.1016/j.gaitpost.2017.01.024. Epub 2017 Feb 9.
Cognitive impairment and gait disorders in people over the age of 65 represent major public health issues because of their high frequency, their link to poor outcomes and high costs. Research has demonstrated that these two geriatric syndromes are closely related.
We aim to review the evidence supporting the relationship between gait and cognitive impairment, particularly focusing on epidemiological and neuropsychological studies in patients with Mild cognitive impairment, Alzheimer's disease and Vascular dementia. The review demonstrates that gait and cognition are closely related, but our knowledge of their interrelationship is limited. Emerging evidence shows that gait analysis has the potential to contribute to diagnosis and prognosis of cognitive impairment.
An integrated approach for evaluating these major geriatric syndromes, based on their close relationship, will not only increase our understanding of cognitive-motor interactions, but most importantly may be used to aid early diagnosis, prognosis and the development of new interventions.
65岁以上人群的认知障碍和步态障碍是重大的公共卫生问题，因其发生率高、与不良后果相关且成本高昂。研究表明，这两种老年综合征密切相关。
我们旨在综述支持步态与认知障碍之间关系的证据，尤其关注轻度认知障碍、阿尔茨海默病和血管性痴呆患者的流行病学和神经心理学研究。该综述表明，步态与认知密切相关，但我们对它们之间相互关系的了解有限。新出现的证据表明，步态分析有可能有助于认知障碍的诊断和预后评估。
基于这些主要老年综合征的密切关系，采用综合方法对其进行评估，不仅会增进我们对认知 - 运动相互作用的理解，更重要的是，可用于辅助早期诊断、预后评估以及新干预措施的开发。
