Ghassemi Fariba, Shields Carol L, Mohebbi Masoumeh, Nili Ahmadabadi Mehdi, Morsali Fatemeh, Sabour Siamak
Ocular Oncology and Retina and Vitreous Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.
Clin Ophthalmol. 2017 Feb 8;11:305-310. doi: 10.2147/OPTH.S121375. eCollection 2017.
The purpose of this study was to investigate the serum hypercoagulability state and common viral and protozoan infections in Coats' disease versus a normal control group.
In this comparative case series, 22 consecutive patients with Coats' disease and 19 non-Coats' patients undergoing lensectomy for congenital, traumatic, or senile cataract between January 2011 and June 2014 were included. Laboratory data for hypercoagulability states and common viral and protozoan infections were investigated.
The mean age for the Coats' group was 14.5 years (median 8 years, range: 2 months to 59 years), and for the control group it was 30.6 years (median 17 years, range: 2-82 years). In patients aged 10 years or younger, anticytomegalovirus immunoglobulin G (IgG) (≤0.01), homocysteine (=0.03), and serum beta globulin (<0.001) were associated with Coats' disease. In those older than 10 years, higher serum protein S (=0.04), beta globulin (=0.05), and gamma globulin (=0.04) were related to Coats' diagnosis. After adjusting for sex and age as confounding factors, only beta globulin was found to be associated with Coats' disease in logistic regression analysis (odds ratio: 1.8, 95% confidence interval: 1.0-3.1, =0.02).
Serum beta globulin levels appear to be elevated in patients with Coats' disease.
本研究旨在调查Coats病患者与正常对照组的血清高凝状态以及常见病毒和原生动物感染情况。
在这个比较性病例系列研究中，纳入了2011年1月至2014年6月期间连续22例Coats病患者以及19例因先天性、外伤性或老年性白内障接受晶状体切除术的非Coats病患者。对高凝状态以及常见病毒和原生动物感染的实验室数据进行了调查。
Coats病组的平均年龄为14.5岁（中位数8岁，范围：2个月至59岁），对照组的平均年龄为30.6岁（中位数17岁，范围：2 - 82岁）。在10岁及以下的患者中，抗巨细胞病毒免疫球蛋白G（IgG）（≤0.01）、同型半胱氨酸（=0.03）和血清β球蛋白（<0.001）与Coats病相关。在10岁以上的患者中，较高的血清蛋白S（=0.04）、β球蛋白（=0.05）和γ球蛋白（=0.04）与Coats病的诊断相关。在将性别和年龄作为混杂因素进行校正后，逻辑回归分析中仅发现β球蛋白与Coats病相关（比值比：1.8，95%置信区间：1.0 - 3.1，=0.02）。
Coats病患者的血清β球蛋白水平似乎升高。
