University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University, Chandigarh, 160 014, India.
Drug Deliv Transl Res. 2018 Apr;8(2):398-413. doi: 10.1007/s13346-017-0364-9.
The primary aim of the present study was to develop lanolin-based organogel with enhanced delivery potential and reduced skin irritation for the treatment of hyperkeratotic lesions and scaling. The drug was encapsulated in the lipidic bilayers of organogel. The values of particle size, polydispersity index (PDI), and zeta potential of the developed carrier system was found to be 257.5 nm, 0.272, and -24.9 mV, respectively. The system was pseudoplastic in nature with the yield value of 2.3078 Pa. The skin permeation studies exhibited superiority of the prepared lanolin-based organogel formulation over the conventional gel formulation (CGF). Further, the dermatokinetic studies also confirmed better permeation and enhanced skin bioavailability of SA to epidermis as well as dermis vis-à-vis the CGF. In conclusion, the developed organogel system not only improved the delivery profile of SA but also reduced the skin irritant potential. The current findings can provide a suitable alternative for the development of an effective topical formulation of SA for the treatment of hyperkeratotic lesions.
本研究的主要目的是开发具有增强的递药潜力和降低皮肤刺激性的羊毛脂基有机凝胶，用于治疗过度角化病变和鳞屑。药物被包裹在有机凝胶的脂质双层中。所开发的载体系统的粒径、多分散指数（PDI）和 Zeta 电位的值分别为 257.5nm、0.272 和-24.9mV。该系统具有假塑性，屈服值为 2.3078Pa。皮肤渗透研究表明，与常规凝胶制剂（CGF）相比，制备的羊毛脂基有机凝胶制剂具有优越性。此外，药代动力学研究也证实，与 CGF 相比，SA 的经皮渗透和表皮及真皮的生物利用度得到了更好的提高。总之，所开发的有机凝胶系统不仅改善了 SA 的递药特性，而且降低了皮肤刺激性潜力。这些发现为开发用于治疗过度角化病变的有效局部 SA 制剂提供了一种合适的替代方案。
