Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge CB2 0RE, UK.
Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
Nat Rev Mol Cell Biol. 2017 May;18(5):279-284. doi: 10.1038/nrm.2017.3. Epub 2017 Feb 22.
Single-stranded guanine-rich DNA sequences can fold into four-stranded DNA structures called G-quadruplexes (G4s) that arise from the self-stacking of two or more guanine quartets. There has been considerable recent progress in the detection and mapping of G4 structures in the human genome and in biologically relevant contexts. These advancements, many of which align with predictions made previously in computational studies, provide important new insights into the functions of G4 structures in, for example, the regulation of transcription and genome stability, and uncover their potential relevance for cancer therapy.
单链富含鸟嘌呤的 DNA 序列可以折叠成四链 DNA 结构，称为 G-四链体 (G4)，它是由两个或更多鸟嘌呤四联体的自堆叠形成的。最近在人类基因组中和生物相关环境中检测和绘制 G4 结构方面取得了相当大的进展。这些进展中的许多都与之前在计算研究中做出的预测相吻合，为 G4 结构在转录调控和基因组稳定性等方面的功能提供了重要的新见解，并揭示了它们在癌症治疗中的潜在相关性。
