Du Dan, Jin Tao, Zhang Rui, Hu Liqiang, Xing Zhihua, Shi Na, Shen Yan, Gong Meng
West China-Washington Mitochondria and Metabolism Center, West China Hospital/West China Medical School, Sichuan University, Chengdu 610041, China.
Department of Integrated Traditional Chinese and Western Medicine, West China Hospital/West China Medical School, Sichuan University, Chengdu 610041, China.
Bioorg Med Chem Lett. 2017 Mar 15;27(6):1467-1470. doi: 10.1016/j.bmcl.2017.01.014. Epub 2017 Jan 7.
One new bibenzyl (1) and one new phenanthrene (2), together with two known bibenzyls (3-4) and four known diarylheptanoids (5-8) were isolated from the rhizomes of Dioscorea zingiberensis. The structures of 1-2 were elucidated by spectroscopic methods including 1D and 2D NMR. Phenols 1-8 were evaluated for their anti-pancreatitic activities on sodium taurocholate (NaT)-induced pancreatic acinars necrosis. Notably, 0.5mM of compound 6 exhibited comparable inhibitory effect with 5mM of caffeine. Furthermore, compound 6 prevented the ATP depletion and excessive ROS production which could be also involved in mitochondria-mediated injuries in acute pancreatitis. As a result, compound 6 has been demonstrated to be a potential candidate for mediating mitochondrial dysfunction to prevent pancreatic necrosis. This study is also the first report on the isolation of bibenzyls and diarylheptanoids from this plant.
从盾叶薯蓣根茎中分离得到一个新的联苄（1）和一个新的菲（2），以及两个已知的联苄（3 - 4）和四个已知的二芳基庚烷类化合物（5 - 8）。通过包括一维和二维核磁共振在内的光谱方法阐明了1 - 2的结构。对酚类化合物1 - 8进行了牛磺胆酸钠（NaT）诱导的胰腺腺泡坏死的抗胰腺炎活性评价。值得注意的是，0.5mM的化合物6与5mM的咖啡因表现出相当的抑制作用。此外，化合物6可防止ATP耗竭和过量ROS产生，这也可能与急性胰腺炎中线粒体介导的损伤有关。结果表明，化合物6是介导线粒体功能障碍以预防胰腺坏死的潜在候选物。本研究也是首次报道从该植物中分离得到联苄和二芳基庚烷类化合物。
