College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University , Seoul , South Korea .
J Enzyme Inhib Med Chem. 2014 Feb;29(1):1-6. doi: 10.3109/14756366.2012.742517. Epub 2013 Jan 18.
Abstract Twenty-three phenolic compounds were isolated from Dioscorea opposita by bioactivity-guided method and their inhibitory effect against pancreatic lipase was evaluated. A total of 15 isolates reduced lipase activity at IC50 values of less than 50 µM and 3,3',5-trihydroxy-2'-methoxybibenzyl showed the highest inhibition with an IC50 value of 8.8 µM. This study is a first to reveal the pancreatic lipase inhibitory activity by both D. opposita and its isolated compounds.
摘要 采用生物活性导向法从薯蓣中分离得到 23 种酚类化合物，并评价其对胰脂肪酶的抑制作用。共有 15 种分离物在 IC50 值小于 50 μM 时降低脂肪酶活性，3,3',5-三羟基-2'-甲氧基二苯并基表现出最高的抑制活性，IC50 值为 8.8 μM。本研究首次揭示了薯蓣及其分离化合物对胰脂肪酶的抑制活性。
