Tilokani Akansha, Agrawal Pratik, Pradhan Prasanti Kumari, Patri Gaurav, Karmakar Nilormi, Sinha Yash
Department of Conservative Dentistry and Endodontics, Kalinga Institute of Dental Sciences, KIIT Deemed to be University, Bhubaneswar, Odisha, India.
J Conserv Dent. 2023 Jan-Feb;26(1):79-82. doi: 10.4103/jcd.jcd_419_22. Epub 2022 Dec 8.
The present experimental study was undertaken to evaluate and compare the antimicrobial activity of triple antibiotic paste (TAP), diclofenac, and proton-pump inhibitor (PPI) against the microorganism Enterococcus faecalis.
Three medicaments were selected for the study, TAP, diclofenac, and PPI. The experimental groups for the test were as follows: Part 1 - Group 1: TAP, Group 2: diclofenac, and Group 3: PPI; Part 2 - Group 1: TAP + PPI and Group 2: diclofenac + PPI. An agar well diffusion test was used to determine the efficacy of the experimental medicaments against E. faecalis (ATCC 29212). The diameter of inhibition zones was measured in millimeters using an inhibition zone measuring scale and the results were recorded.
The statistical analysis was done using an analysis of variance and an unpaired -test. value was set at < 0.05.
There was a significant difference in the diameter of growth inhibition zones, with the greatest diameter noted for TAP + PPI followed by diclofenac sodium (DS) + PPI, TAP, DS, and PPI.
The antimicrobial effectiveness of TAP + PPI was found to be superior to all other medicaments (DS + PPI, TAP, DS, and PPI).
进行本实验研究以评估和比较三联抗生素糊剂（TAP）、双氯芬酸和质子泵抑制剂（PPI）对粪肠球菌的抗菌活性。
选择三种药物进行研究，即TAP、双氯芬酸和PPI。测试的实验组如下：第1部分 - 第1组：TAP，第2组：双氯芬酸，第3组：PPI；第2部分 - 第1组：TAP + PPI，第2组：双氯芬酸 + PPI。采用琼脂孔扩散试验来确定实验药物对粪肠球菌（ATCC 29212）的疗效。使用抑菌圈测量尺以毫米为单位测量抑菌圈直径，并记录结果。
采用方差分析和非配对t检验进行统计分析。设定P值<0.05。
生长抑制圈直径存在显著差异，TAP + PPI的直径最大，其次是双氯芬酸钠（DS）+ PPI、TAP、DS和PPI。
发现TAP + PPI的抗菌效果优于所有其他药物（DS + PPI、TAP、DS和PPI）。
