Kortas Jakub, Kuchta Agnieszka, Prusik Krzysztof, Prusik Katarzyna, Ziemann Ewa, Labudda Sandra, Ćwiklińska Agnieszka, Wieczorek Ewa, Jankowski Maciej, Antosiewicz Jedrzej
Department of Recreation and Qualify Tourism, Gdansk University of Physical Education and Sport, Kazimierza Górskiego 1, 80-336, Gdansk, Poland.
Department of Clinical Chemistry, Medical University of Gdansk, Gdansk, Poland.
Biogerontology. 2017 Aug;18(4):517-524. doi: 10.1007/s10522-017-9681-0. Epub 2017 Feb 22.
Excess body iron accumulation and oxidative stress has been associated with ageing. Regular exercise has been shown to reduce oxidative stress and induce some changes in iron metabolism. However, the effects of exercise on both of these parameters have been poorly investigated. In our study, 35 elderly women participated in 12 weeks of Nordic walking (NW) training (three times a week). We demonstrated that the training caused a significant reduction in malondialdehyde advanced oxidation protein products-markers of oxidative stress but had no effects on paraoxonase 1 activity. These changes were associated with the decrease of blood ferritin (99.4 ± 62.7 vs. 81.4 ± 61.7 ng/ml p < 0.05). Measurement of physical fitness revealed that the training caused a significant improvement in performance and a negative correlation between the blood ferritin and endurance test was recorded (r = -0.34, p = 0.03). In addition, a significant correlation between blood ferritin and fasting glucose level was noted. The training induced a rise of HDL cholesterol from 70.8 ± 19.3-75.3 ± 21.1, p < 0.05, whereas other lipid parameters remained unchanged. In conclusion, NW training reduced body iron stores and it was associated with lower oxidative stress and better endurance.
体内铁过量蓄积和氧化应激与衰老相关。已有研究表明，规律运动可降低氧化应激，并引起铁代谢的一些变化。然而，运动对这两个参数的影响尚未得到充分研究。在我们的研究中，35名老年女性参加了为期12周的北欧健走（NW）训练（每周三次）。我们发现，该训练使丙二醛（氧化应激标志物）和晚期氧化蛋白产物显著降低，但对对氧磷酶1活性没有影响。这些变化与血铁蛋白降低相关（99.4±62.7 vs. 81.4±61.7 ng/ml，p<0.05）。体能测试显示，训练使运动能力显著提高，且血铁蛋白与耐力测试呈负相关（r = -0.34，p = 0.03）。此外，血铁蛋白与空腹血糖水平之间存在显著相关性。训练使高密度脂蛋白胆固醇从70.8±19.3升高至75.3±21.1，p<0.05，而其他血脂参数保持不变。总之，北欧健走训练减少了体内铁储存，并与较低的氧化应激和更好的耐力相关。
