Kortas Jakub, Prusik Katarzyna, Flis Damian, Prusik Krzysztof, Ziemann Ewa, Leaver Neil, Antosiewicz Jedrzej
Department of Recreation and Tourism, Gdansk University of Physical Education and Sport, Gdansk, Poland.
Department of Biomedical Basis of Health, Gdansk University of Physical Education and Sport, Gdansk, Poland.
Clin Interv Aging. 2015 Nov 27;10:1889-96. doi: 10.2147/CIA.S90413. eCollection 2015.
Despite several, well-documented pro-healthy effects of regular physical training, its influence on body iron stores in elderly people remains unknown. At the same time, body iron accumulation is associated with high risk of different morbidities.
We hypothesized that Nordic Walking training would result in pro-healthy changes in an elderly group of subjects by reducing body iron stores via shifts in iron metabolism-regulating proteins.
Thirty-seven women aged 67.7±5.3 years participated in this study. They underwent 32 weeks of training, 1-hour sessions three times a week, between October 2012 and May 2013. Fitness level, blood morphology, CRP, vitamin D, ferritin, hepcidin, and soluble Hjv were assessed before and after the training.
The training program caused a significant decrease in ferritin, which serves as a good marker of body iron stores. Simultaneously, the physical cardiorespiratory fitness had improved. Furthermore, blood hepcidin was positively correlated with the ferritin concentration after the training. The concentration of blood CRP dropped, but the change was nonsignificant. The applied training resulted in a blood Hjv increase, which was inversely correlated with the vitamin D concentration.
Overall the Nordic Walking training applied in elderly people significantly reduced blood ferritin concentration, which explains the observed decrease in body iron stores.
尽管定期体育锻炼对健康有诸多已被充分记录的积极影响，但其对老年人身体铁储备的影响仍不明确。与此同时，身体铁蓄积与多种疾病的高风险相关。
我们假设，北欧健走训练可通过调节铁代谢的蛋白质变化来减少身体铁储备，从而使老年受试者群体产生有益健康的改变。
37名年龄在67.7±5.3岁的女性参与了本研究。她们在2012年10月至2013年5月期间接受了为期32周的训练，每周三次，每次1小时。在训练前后评估了身体适应能力、血液形态、CRP、维生素D、铁蛋白、铁调素和可溶性Hjv。
训练计划使铁蛋白显著降低，铁蛋白是身体铁储备的良好指标。同时，心肺适能有所改善。此外，训练后血液中的铁调素与铁蛋白浓度呈正相关。血液中CRP浓度下降，但变化不显著。所进行的训练导致血液中Hjv增加，且与维生素D浓度呈负相关。
总体而言，应用于老年人的北欧健走训练显著降低了血液中铁蛋白浓度，这解释了所观察到的身体铁储备的减少。
