Tarazona Guillermo, Schleissner Carmen, Rodríguez Pilar, Pérez Marta, Cañedo Librada Ma, Cuevas Carmen
Research & Development Department, PharmaMar S. A. , Pol. Ind. La Mina Norte, Avenida de los Reyes 1, 28770, Colmenar Viejo, Madrid, Spain.
J Nat Prod. 2017 Apr 28;80(4):1034-1038. doi: 10.1021/acs.jnatprod.6b01057. Epub 2017 Feb 23.
A marine-derived bacterium, Streptomyces misionensis BAT-10-03-123, has produced four new streptenol derivatives, F, G, H, and I (1-4), as well as the known streptenols A and C (5 and 6). Their planar structures were elucidated by detailed analysis of spectroscopic data. The absolute configurations of the new streptenol compounds were determined by chemical and spectroscopic methods, including Mosher's ester method. All of the compounds were tested for cytotoxicity against four selected cancer cell lines.
一种源自海洋的细菌,米申链霉菌BAT - 10 - 03 - 123,产生了四种新的链烯醇衍生物F、G、H和I(1 - 4),以及已知的链烯醇A和C(5和6)。通过对光谱数据的详细分析阐明了它们的平面结构。通过化学和光谱方法,包括莫舍尔酯法,确定了新链烯醇化合物的绝对构型。测试了所有化合物对四种选定癌细胞系的细胞毒性。