宫内生长受限和女性性别对未来血压及心血管疾病的影响。
Effects of Intrauterine Growth Restriction and Female Sex on Future Blood Pressure and Cardiovascular Disease.
作者信息
Davis Gwendolyn K, Newsome Ashley D, Ojeda Norma B, Alexander Barbara T
机构信息
Department of Physiology and Biophysics, Women's Health Research Center, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Departments of Pediatrics, 2500 North State Street, Jackson, MS, 39216, USA.
出版信息
Curr Hypertens Rep. 2017 Feb;19(2):13. doi: 10.1007/s11906-017-0712-7.
PURPOSE OF THE REVIEW
It is well-established that the age-related increase in blood pressure is augmented after menopause. Yet, the prevalence of hypertension is enhanced in low birth weight women relative to normal birth weight counterparts by 60 years of age suggesting that adverse influences during fetal life heighten cardiovascular risk in later life.
RECENT FINDINGS
A changing hormonal milieu may contribute to increased cardiovascular risk that occurs after the menopausal transition. Low birth weight is associated with early age at menopause. A recent study indicates that a shift towards testosterone excess following early reproductive senescence may contribute to the etiology of age-dependent increases in blood pressure in a rodent model of low birth weight. This review will highlight current findings related to postmenopausal hypertension and discuss potential mechanisms that may contribute to the enhanced cardiovascular risk that develops with age in low birth weight women.
综述目的
众所周知，绝经后血压随年龄增长的幅度会增大。然而，到60岁时，低出生体重女性的高血压患病率相对于正常出生体重女性有所增加，这表明胎儿期的不良影响会增加日后患心血管疾病的风险。
最新研究结果
激素环境的变化可能导致绝经过渡后心血管疾病风险增加。低出生体重与绝经年龄提前有关。最近一项研究表明，在低出生体重啮齿动物模型中，早期生殖衰老后睾酮过量的转变可能是血压随年龄增长而升高的病因之一。本综述将重点介绍绝经后高血压的当前研究结果，并讨论可能导致低出生体重女性随年龄增长心血管疾病风险增加的潜在机制。
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