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自闭症谱系障碍儿童的唾液生物标志物水平与口腔健康状况:一项对比研究。

Salivary biomarker levels and oral health status of children with autistic spectrum disorders: a comparative study.

作者信息

Bhandary S, Hari N

机构信息

Department of Paedodontics and Preventive Dentistry, A.B. Shetty Memorial Institute of Dental Sciences, Nitte University, Deralakatte, Mangalore, Karnataka, 575018, India.

出版信息

Eur Arch Paediatr Dent. 2017 Apr;18(2):91-96. doi: 10.1007/s40368-017-0275-y. Epub 2017 Feb 24.

Abstract

AIM

To evaluate the oral health status, salivary flow rate, pH and buffering capacity in children with autistic spectrum disorders (ASD) in comparison to their healthy siblings.

METHODS

A total of 30 subjects with ASD and 30 normal healthy siblings between the ages of 6-12 years of both genders attending various special schools and hospitals of Mangalore, India were recruited. Estimation of salivary pH, flow rate and buffering capacity were performed and oral health status was assessed using the WHO oral assessment form for children (World Health Organization in Oral health surveys: basic methods, World Health Organization, Geneva, 2013). The oral hygiene of the subjects was assessed using the oral hygiene index-simplified. Dental erosive lesions, presence of mucosal lesions and dental trauma were recorded for both the study and the control groups.

RESULTS

It was observed that salivary pH and buffering capacity were lower in children with ASD than their healthy siblings, the dental caries incidence was higher in ASD children when compared to their healthy siblings and oral hygiene was fair with gingival bleeding in children with ASD.

CONCLUSIONS

This study clearly indicates a need for better home care measures, parent, caregiver and institutional education on the importance of oral well-being among children with ASD.

摘要

目的

评估自闭症谱系障碍(ASD)儿童与其健康兄弟姐妹相比的口腔健康状况、唾液流速、pH值和缓冲能力。

方法

招募了印度芒格洛尔各特殊学校和医院中30名年龄在6至12岁之间的患有ASD的受试者以及30名正常健康的兄弟姐妹,男女不限。进行唾液pH值、流速和缓冲能力的测定,并使用世界卫生组织儿童口腔评估表(世界卫生组织,《口腔健康调查:基本方法》,世界卫生组织,日内瓦,2013年)评估口腔健康状况。使用简化口腔卫生指数评估受试者的口腔卫生状况。记录研究组和对照组的牙齿侵蚀性病变、黏膜病变和牙齿外伤情况。

结果

观察到ASD儿童的唾液pH值和缓冲能力低于其健康兄弟姐妹,ASD儿童的龋齿发病率高于其健康兄弟姐妹,且ASD儿童的口腔卫生状况一般,伴有牙龈出血。

结论

本研究明确表明,需要采取更好的家庭护理措施,对家长、照顾者和机构进行关于ASD儿童口腔健康重要性的教育。

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