2014年越南河内医院确诊麻疹儿童中的病毒合并感染情况。

Viral co-infections among children with confirmed measles at hospitals in Hanoi, Vietnam, 2014.

作者信息

Hang Le Khanh Nguyen, Do Loan Phuong, Van Thanh Thi Trieu, Nguyen Son Vu, Hoang Phuong Vu Mai, Pham Hien Thi, Le Thanh Thi, Tran Huong Thi Thu, Vuong Cuong Duc, Mai Thi Quynh Le

机构信息

National Institute of Hygiene and Epidemiology, No 1-Yesrsin Street, Hanoi, Viet Nam.

出版信息

Asian Pac J Trop Med. 2017 Feb;10(2):171-174. doi: 10.1016/j.apjtm.2017.01.015. Epub 2017 Jan 20.

DOI:10.1016/j.apjtm.2017.01.015

PMID:28237484

Abstract

OBJECTIVE

To characterize viral co-infections among representative hospitalized measles cases during the 2014 Hanoi outbreak.

METHODS

Throat swabs were collected from 54 pediatric patients with confirmed measles, and molecular diagnostics performed for 10 additional viral respiratory pathogens (Influenza A/H1N1pdm09; A/H3N2 and influenza B; Parainfluenza 1, 2, 3; Respiratory Synctial Virus, RSV; human Metapneumovirus, hMPV; Adenovirus and Picornavirus).

RESULTS

Twenty-one cases (38.9%) showed evidence of infection with other respiratory viruses: 15 samples contained measles plus one additional virus, and 6 samples contained measles plus 2 additional viruses. Adenovirus was detected as a predominant cause of co-infections (13 cases; 24.1%), followed by RSV (6 cases; 11.1%), A/H1N1pdm09 (3 cases; 5.6%), PIV3 (3 cases; 3.7%), Rhinovirus (3 cases; 3.7%) and hMPV (1 case; 1.96%).

CONCLUSIONS

Viral co-infections identified from pediatric measles cases may have contributed to increased disease severity and high rate of fatal outcomes. Optimal treatment of measles cases may require control of multiple viral respiratory pathogens.

摘要

目的

对2014年河内麻疹暴发期间有代表性的住院麻疹病例中的病毒合并感染情况进行特征描述。

方法

从54例确诊麻疹的儿科患者中采集咽拭子，并对另外10种病毒性呼吸道病原体（甲型H1N1pdm09流感病毒；甲型H3N2流感病毒和乙型流感病毒；副流感病毒1型、2型、3型；呼吸道合胞病毒，RSV；人偏肺病毒，hMPV；腺病毒和小RNA病毒）进行分子诊断。

结果

21例（38.9%）病例显示有感染其他呼吸道病毒的证据：15份样本检测出麻疹病毒加另外一种病毒，6份样本检测出麻疹病毒加另外两种病毒。腺病毒被检测为合并感染的主要病因（13例；24.1%），其次是呼吸道合胞病毒（6例；11.1%）、甲型H1N1pdm09流感病毒（3例；5.6%）、副流感病毒3型（3例；3.7%）、鼻病毒（3例；3.7%）和人偏肺病毒（1例；1.96%）。