Khademvatan Shahram, Foroutan Masoud, Hazrati-Tappeh Khosrow, Dalvand Sahar, Khalkhali Hamidreza, Masoumifard Sajjad, Hedayati-Rad Faezeh
Cellular and Molecular Research Center & Department of Medical Parasitology and Mycology, Urmia University of Medical Sciences, Urmia, Iran.
Department of Parasitology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran; Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran.
J Infect Public Health. 2017 Sep-Oct;10(5):487-493. doi: 10.1016/j.jiph.2017.01.021. Epub 2017 Feb 23.
During recent years, implication of rodents in the epidemiology of Toxoplasma gondii is overlooked in Iran; thus, we performed a systematic review and meta-analysis to evaluate the prevalence of toxoplasmosis in rodents of Iran. For this purpose, following the general methodology recommended for systematic reviews and meta-analysis, 5 English and 3 Persian databases were explored from 1 January 2000 till 10 September 2016 using related keywords. Finally, 9 out of 291 citations were met to be included in this study. Due to significant heterogeneity, the random-effects model was conducted (I=93.55%). During the years, 661 rodents were trapped, and 121 of them were identified positive for T. gondii 15% (95% CI=5-27). Moreover, overall prevalence using direct microscopic examination (1/230), PCR-based techniques (41/246) and serological tests (83/437) was obtained 0.1% (95% CI=0.0-1.5), 18% (95% CI=4-39) and 15% (95% CI=3-33), respectively. Our study revealed the prevalence of toxoplasmosis in rodents is remarkable. Considering this fact, they play a key role in the life cycle of T. gondii and should not be neglected. Further surveys is needed to better recognize the role of various rodent species in distribution of toxoplasmosis.
近年来，伊朗忽视了啮齿动物在弓形虫病流行病学中的作用；因此，我们进行了一项系统评价和荟萃分析，以评估伊朗啮齿动物中弓形虫病的患病率。为此，按照系统评价和荟萃分析推荐的一般方法，从2000年1月1日至2016年9月10日，使用相关关键词对5个英文数据库和3个波斯文数据库进行了检索。最后，291篇文献中有9篇符合纳入本研究的标准。由于存在显著异质性，采用随机效应模型（I=93.55%）。这些年来，共捕获661只啮齿动物，其中121只被鉴定为弓形虫阳性，患病率为15%（95%CI=5-27）。此外，采用直接显微镜检查（1/230）、基于PCR的技术（41/246）和血清学检测（83/437）得出的总体患病率分别为0.1%（95%CI=0.0-1.5）、18%（95%CI=4-39）和15%（95%CI=3-33）。我们的研究表明，啮齿动物中弓形虫病的患病率相当高。鉴于这一事实，它们在弓形虫的生命周期中起着关键作用，不应被忽视。需要进一步的调查，以更好地认识各种啮齿动物物种在弓形虫病传播中的作用。
