Galeh Tahereh Mikaeili, Sarvi Shahabeddin, Montazeri Mahbobeh, Moosazadeh Mahmood, Nakhaei Maryam, Shariatzadeh Seyyed Ali, Daryani Ahmad
Department of Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Front Vet Sci. 2020 Jul 31;7:461. doi: 10.3389/fvets.2020.00461. eCollection 2020.
Toxoplasmosis is one of the most prevalent infections in humans and animals caused by the intracellular protozoan parasite (). Rodents, as intermediate and reservoir hosts, play a key role in the maintenance and transmission of . They can be contaminated and maintain the parasite in the form of cysts in their bodies, demonstrating an infection source for their offsprings, predators (particularly felids), and other animals. Therefore, the present systematic review and meta-analysis study was carried out to evaluate the global seroprevalence of in these mammals. For achieving the purpose of the current study, six English databases (PubMed, Science Direct, Web of Science, Scopus, ProQuest, and Google Scholar) were systematically searched for related studies from 1970 to 2018. Finally, a total of 52,372 records were screened, 105 records including 26,221 rodents were incorporated in the present study. By random effect models, the overall seroprevalence was calculated at 6% (95% CI = 6-7%), with the highest amount was observed in Africa (24%) and South America (18%), and the lowest amount in Europe (1%). The subgroup data analysis by gender manifested that the prevalence of Immunoglobulin G antibodies did not differ between genders ( > 0.05). Due to the significant heterogeneity, meta-regression models were applied based on serological techniques and continental regions; however, the obtained values were not statistically significant ( = 0.480 and = 0.295, respectively). The present study revealed a relatively low level of seroprevalence in rodents; however, if they were the main food source for their predators, they would cause high transmission of .
弓形虫病是由细胞内原生动物寄生虫（）引起的人类和动物中最普遍的感染之一。啮齿动物作为中间宿主和储存宿主，在（该寄生虫）的维持和传播中起关键作用。它们可能被污染并在体内以囊肿形式维持寄生虫，这对其后代、捕食者（特别是猫科动物）和其他动物构成感染源。因此，开展了本系统评价和荟萃分析研究，以评估这些哺乳动物中（弓形虫）的全球血清阳性率。为实现本研究目的，系统检索了六个英文数据库（PubMed、Science Direct、Web of Science、Scopus、ProQuest和谷歌学术）中1970年至2018年的相关研究。最后，共筛选出52372条记录，本研究纳入了105条记录，包括26221只啮齿动物。通过随机效应模型，计算出总体血清阳性率为6%（95%CI = 6 - 7%），其中非洲（24%）和南美洲（18%）的血清阳性率最高，欧洲（1%）最低。按性别进行的亚组数据分析表明，免疫球蛋白G抗体的患病率在性别之间没有差异（>0.05）。由于存在显著异质性，基于血清学技术和大陆区域应用了荟萃回归模型；然而，得到的值没有统计学意义（分别为=0.480和=0.295）。本研究揭示了啮齿动物中弓形虫血清阳性率相对较低；然而，如果它们是捕食者的主要食物来源，就会导致弓形虫的高传播。
